EC Number | Cloned (Comment) | Organism |
---|---|---|
1.18.1.2 | overexpressed in Escherichia coli | Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.18.1.2 | 0.0008 | - |
oxidized ferredoxin | Plasmodium falciparum ferredoxin PfFd is tested;using cytochrome c as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 0.0055 | - |
NADPH | using cytochrome c as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 0.01 | - |
NADPH | using K3Fe(CN)6 as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 0.05 | - |
NADPH | using 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride as electron acceptor | Plasmodium falciparum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.18.1.2 | Plasmodium falciparum | C6KT68 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.18.1.2 | - |
Plasmodium falciparum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.18.1.2 | NADPH + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride | - |
Plasmodium falciparum | NADP+ + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride | - |
? | |
1.18.1.2 | NADPH + K3Fe(CN)6 | - |
Plasmodium falciparum | NADP+ + reduced K3Fe(CN)6 | - |
r | |
1.18.1.2 | NADPH + oxidized cytochrome c | - |
Plasmodium falciparum | NADP+ + reduced cytochrome c | - |
r | |
1.18.1.2 | NADPH + oxidized ferredoxin | - |
Plasmodium falciparum | NADP+ + reduced ferredoxin | - |
? | |
1.18.1.2 | oxidized ferredoxin + NADPH + H+ | - |
Plasmodium falciparum | reduced ferredoxin + NADP+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.18.1.2 | More | Under oxidizing conditions, Plasmodium falciparum FNR constitutes an inactive dimeric form stabilized by an intermolecular disulfide bond. Monomer-dimer interconversion can be controlled by oxidizing and reducing agents that are possibly present within the apicoplast, such as H2O2, glutathione, and lipoate. | Plasmodium falciparum |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.18.1.2 | ferredoxin-NADP+ reductase | - |
Plasmodium falciparum |
1.18.1.2 | FNR | - |
Plasmodium falciparum |
1.18.1.2 | PfFNR | ferredoxin-NADP+ reductase of Plasmodium falciparum | Plasmodium falciparum |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.18.1.2 | 7.5 | - |
NADPH | using cytochrome c as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 65 | - |
NADPH | using 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 85 | - |
NADPH | using K3Fe(CN)6 as electron acceptor | Plasmodium falciparum |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.18.1.2 | 1200 | - |
NADPH | using cytochrome c as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 1300 | - |
NADPH | using 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 8000 | - |
Ferredoxin | Plasmodium falciparum ferredoxin PfFd is tested;using cytochrome c as electron acceptor | Plasmodium falciparum | |
1.18.1.2 | 8500 | - |
NADPH | using K3Fe(CN)6 as electron acceptor | Plasmodium falciparum |