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Literature summary extracted from

  • Salmon, A.B.; Perez, V.I.; Bokov, A.; Jernigan, A.; Kim, G.; Zhao, H.; Levine, R.L.; Richardson, A.
    Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span (2009), FASEB J., 23, 3601-3608.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin Mus musculus
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin
-
 Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Mus musculus
1.8.4.11 MsrA
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.8.4.11 physiological function methionine sulfoxide reductase A repairs oxidized methionine residues within proteins and may also function as a general antioxidant, lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span, MsrA knockout mice are more susceptible to oxidative stress induced by paraquat, there is no difference between MsrA knockout and control mice in either their median or maximum life span Mus musculus