Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wadham, C.; Mangoni, A.A.
    Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease (2009), Expert. Opin. Drug Metab. Toxicol., 5, 303-319.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.3.18 adiponectin
-
 Homo sapiens
3.5.3.18 all-trans-retinoic acid 1.9fold increase in DDAH-2 mRNA and protein expression Mus musculus
3.5.3.18 aminoguanidine
-
 Rattus norvegicus
3.5.3.18 aspirin
-
 Rattus norvegicus
3.5.3.18 EDTA
-
 Rattus norvegicus
3.5.3.18 epigallocatechin gallate
-
 Homo sapiens
3.5.3.18 fenofibrate
-
 Homo sapiens
3.5.3.18 Insulin
-
 Homo sapiens
3.5.3.18 interleukin-1beta
-
 Rattus norvegicus
3.5.3.18 interleukin-1beta 2fold increase in DDAH-1 protein expression Rattus norvegicus
3.5.3.18 losartan
-
 Homo sapiens
3.5.3.18 nebivolol 2fold increase in DDAH-2 mRNA and protein expression Homo sapiens
3.5.3.18 oestradiol 60-70% increase in DDAH-2 mRNA and protein expression Homo sapiens
3.5.3.18 pioglitazone 2-3fold increase of DDAH-2 mRNA and protein levels Rattus norvegicus
3.5.3.18 pravastatin
-
 Rattus norvegicus
3.5.3.18 probucol
-
 Homo sapiens
3.5.3.18 taurin
-
 Bos taurus
3.5.3.18 taurin
-
 Rattus norvegicus
3.5.3.18 taurin
-
 Homo sapiens
3.5.3.18 taurine
-
 Oryctolagus cuniculus
3.5.3.18 taurine
-
 Mus musculus
3.5.3.18 telmisartan
-
 Bos taurus
3.5.3.18 telmisartan
-
 Oryctolagus cuniculus
3.5.3.18 telmisartan
-
 Rattus norvegicus
3.5.3.18 telmisartan
-
 Mus musculus
3.5.3.18 telmisartan
-
 Homo sapiens
3.5.3.18 vitamin E
-
 Bos taurus
3.5.3.18 vitamin E
-
 Oryctolagus cuniculus
3.5.3.18 vitamin E
-
 Rattus norvegicus
3.5.3.18 vitamin E
-
 Mus musculus
3.5.3.18 vitamin E
-
 Homo sapiens
3.5.3.18 xanthone
-
 Bos taurus
3.5.3.18 xanthone
-
 Oryctolagus cuniculus
3.5.3.18 xanthone
-
 Rattus norvegicus
3.5.3.18 xanthone
-
 Mus musculus
3.5.3.18 xanthone
-
 Homo sapiens

Application

EC Number Application Comment Organism
3.5.3.18 medicine influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis Bos taurus
3.5.3.18 medicine influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis Oryctolagus cuniculus
3.5.3.18 medicine influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis Rattus norvegicus
3.5.3.18 medicine influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis Mus musculus
3.5.3.18 medicine influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.18 2-(N,N-dimethylamino)diazenolate-2-oxide 1 mM, 50% inhibition of DDAH-1 Homo sapiens
3.5.3.18 2-(N,N-dimethylamino)diazenolate-2-oxide 1 mM, 50% inhibition of DDAH-1; 1 mM, 50% inhibition of DDAH-1 Mus musculus
3.5.3.18 2-(N,N-dimethylamino)diazenolate-2-oxide 1 mM, 50% inhibition of DDAH-1 Rattus norvegicus
3.5.3.18 4-hydroxy-2-nonenal 50 microM, 50% relative activity Homo sapiens
3.5.3.18 angiotensin II 1 microM, about 55% relative activity; 1 microM, about 55% relative activity Homo sapiens
3.5.3.18 cytokine induced nitric-oxide synthesis
-
 Homo sapiens
3.5.3.18 erythropoetin 200 units/ml, about 75% relative activity; 200 units/ml, about 75% relative activity Homo sapiens
3.5.3.18 glucose
-
 Homo sapiens
3.5.3.18 glucose 25.5 mmol/l; 25.5 mmol/l Mus musculus
3.5.3.18 glucose 25.5 mmol/l; 25.5 mmol/l Rattus norvegicus
3.5.3.18 glycosylated bovine serum albumin
-
 Rattus norvegicus
3.5.3.18 homocysteine
-
 Homo sapiens
3.5.3.18 hydrogen peroxide 100 microM, 50% relative activity Homo sapiens
3.5.3.18 lipopolysaccharide 1 microg/ml, 24 h, about 55% relative activity; 1 microg/ml, about 55% relative activity Homo sapiens
3.5.3.18 low-density-lipoprotein 100 microg/ml Homo sapiens
3.5.3.18 lysophosphatidylcholine 10 microg/ml, about 35% relative activity Homo sapiens
3.5.3.18 Mercuric chloride
-
 Rattus norvegicus
3.5.3.18 N-(2-methoxyethyl)-L-arginine complete inhibition at 100 microM; complete inhibition at 100 microM Rattus norvegicus
3.5.3.18 N-(2-methoxyethyl)arginine
-
 Mus musculus
3.5.3.18 N-(2-methoxyethyl)arginine methyl esther
-
 Mus musculus
3.5.3.18 N-nitro-L-arginine methylester 1 mM, 1 h, 47.1% relative activity; 1mM, 1 h, 47.1% relative activity Bos taurus
3.5.3.18 N-nitro-L-arginine methylester 1mM, 1 h, 47.1% relative activity Homo sapiens
3.5.3.18 N-nitro-L-arginine methylester
-
 Mus musculus
3.5.3.18 N-nitro-L-arginine methylester 1 mM, 1 h, 47.1% relative activity Oryctolagus cuniculus
3.5.3.18 N-nitro-L-arginine methylester
-
 Rattus norvegicus
3.5.3.18 Nicotine 50% decrease in DDAH-2 mRNA Homo sapiens
3.5.3.18 nitric oxide increased NO production nitrosates DDAH Homo sapiens
3.5.3.18 nitroglycerine 10 microM, 16 h, about 55% relative activity; 10 microM, about 55% relative activity Homo sapiens
3.5.3.18 peroxynitrite
-
 Homo sapiens
3.5.3.18 S-2-amino-4-[N-(2-methoxyethyl)guanidino]butanoic acid benzyl ester
-
 Rattus norvegicus
3.5.3.18 TNF-alpha 250 U/ml, 63% relative activity Homo sapiens
3.5.3.18 Zn2+ 20 microM, 40% relative activity; 20 microM, 40% relative activity Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.3.18 0.18
-
 dimethyl-L-arginine
-
 Bos taurus
3.5.3.18 0.18
-
 dimethyl-L-arginine
-
 Oryctolagus cuniculus
3.5.3.18 0.18
-
 dimethyl-L-arginine
-
 Rattus norvegicus
3.5.3.18 0.18
-
 dimethyl-L-arginine
-
 Mus musculus
3.5.3.18 0.18
-
 dimethyl-L-arginine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.18 Bos taurus
-
-
-
3.5.3.18 Bos taurus Q3SX44
-
-
3.5.3.18 Homo sapiens O94760
-
-
3.5.3.18 Homo sapiens O95865
-
-
3.5.3.18 Mus musculus Q99LD8
-
-
3.5.3.18 Mus musculus Q9CWS0
-
-
3.5.3.18 Oryctolagus cuniculus
-
-
-
3.5.3.18 Rattus norvegicus O08557
-
-
3.5.3.18 Rattus norvegicus Q6MG60
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.18 aortic endothelial cell
-
 Rattus norvegicus
-
3.5.3.18 brain
-
 Bos taurus
-
3.5.3.18 ECV304 cell
-
 Homo sapiens
-
3.5.3.18 endothelial cell sEnd-1 cells Mus musculus
-
3.5.3.18 heart
-
 Oryctolagus cuniculus
-
3.5.3.18 heart
-
 Rattus norvegicus
-
3.5.3.18 heart
-
 Mus musculus
-
3.5.3.18 heart
-
 Homo sapiens
-
3.5.3.18 heart
-
 Bos taurus
-
3.5.3.18 HUVEC cell
-
 Homo sapiens
-
3.5.3.18 kidney
-
 Bos taurus
-
3.5.3.18 kidney
-
 Oryctolagus cuniculus
-
3.5.3.18 kidney
-
 Rattus norvegicus
-
3.5.3.18 kidney
-
 Mus musculus
-
3.5.3.18 kidney
-
 Homo sapiens
-
3.5.3.18 liver
-
 Bos taurus
-
3.5.3.18 liver
-
 Oryctolagus cuniculus
-
3.5.3.18 liver
-
 Mus musculus
-
3.5.3.18 liver
-
 Rattus norvegicus
-
3.5.3.18 liver
-
 Homo sapiens
-
3.5.3.18 placenta
-
 Oryctolagus cuniculus
-
3.5.3.18 placenta
-
 Rattus norvegicus
-
3.5.3.18 placenta
-
 Mus musculus
-
3.5.3.18 placenta
-
 Homo sapiens
-
3.5.3.18 placenta
-
 Bos taurus
-
3.5.3.18 pulmonary artery endothelial cell
-
 Mus musculus
-
3.5.3.18 smooth muscle
-
 Rattus norvegicus
-
3.5.3.18 umbilical vein endothelial cell
-
 Homo sapiens
-
3.5.3.18 vascular endothelium
-
 Oryctolagus cuniculus
-
3.5.3.18 vascular endothelium
-
 Rattus norvegicus
-
3.5.3.18 vascular endothelium
-
 Mus musculus
-
3.5.3.18 vascular endothelium
-
 Homo sapiens
-
3.5.3.18 vascular endothelium
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.18 dimethyl-L-arginine + H2O
-
 Bos taurus L-citrulline + dimethylamine
-
 ?
3.5.3.18 dimethyl-L-arginine + H2O
-
 Oryctolagus cuniculus L-citrulline + dimethylamine
-
 ?
3.5.3.18 dimethyl-L-arginine + H2O
-
 Rattus norvegicus L-citrulline + dimethylamine
-
 ?
3.5.3.18 dimethyl-L-arginine + H2O
-
 Mus musculus L-citrulline + dimethylamine
-
 ?
3.5.3.18 dimethyl-L-arginine + H2O
-
 Homo sapiens L-citrulline + dimethylamine
-
 ?
3.5.3.18 Ngamma-monomethyl-L-arginine + H2O
-
 Bos taurus L-citrulline + methylamine
-
 ?
3.5.3.18 Ngamma-monomethyl-L-arginine + H2O
-
 Oryctolagus cuniculus L-citrulline + methylamine
-
 ?
3.5.3.18 Ngamma-monomethyl-L-arginine + H2O
-
 Rattus norvegicus L-citrulline + methylamine
-
 ?
3.5.3.18 Ngamma-monomethyl-L-arginine + H2O
-
 Mus musculus L-citrulline + methylamine
-
 ?
3.5.3.18 Ngamma-monomethyl-L-arginine + H2O
-
 Homo sapiens L-citrulline + methylamine
-
 ?
3.5.3.18 S-methyl-L-thiocitrulline + H2O
-
 Bos taurus L-citrulline + methanethiol
-
 ?
3.5.3.18 S-methyl-L-thiocitrulline + H2O
-
 Oryctolagus cuniculus L-citrulline + methanethiol
-
 ?
3.5.3.18 S-methyl-L-thiocitrulline + H2O
-
 Rattus norvegicus L-citrulline + methanethiol
-
 ?
3.5.3.18 S-methyl-L-thiocitrulline + H2O
-
 Mus musculus L-citrulline + methanethiol
-
 ?
3.5.3.18 S-methyl-L-thiocitrulline + H2O
-
 Homo sapiens L-citrulline + methanethiol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.18 DDAH-1
-
 Bos taurus
3.5.3.18 DDAH-1
-
 Oryctolagus cuniculus
3.5.3.18 DDAH-1
-
 Mus musculus
3.5.3.18 DDAH-1
-
 Rattus norvegicus
3.5.3.18 DDAH-1
-
 Homo sapiens
3.5.3.18 DDAH-2
-
 Oryctolagus cuniculus
3.5.3.18 DDAH-2
-
 Rattus norvegicus
3.5.3.18 DDAH-2
-
 Mus musculus
3.5.3.18 DDAH-2
-
 Homo sapiens
3.5.3.18 DDAH-2
-
 Bos taurus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Bos taurus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Oryctolagus cuniculus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Rattus norvegicus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Mus musculus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Homo sapiens