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Literature summary extracted from
- Targeting neutrophil elastase in cystic fibrosis (2008), Expert Opin. Ther. Targets, 12, 145-157.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.37 | medicine | neutrophil elastase is a target fot therapies in the treatment of cystic fibrosis | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.37 | alpha-1-antitrypsin | - |
Homo sapiens | |
| 3.4.21.37 | antipain | - |
Homo sapiens |  |
| 3.4.21.37 | chymostatin | - |
Homo sapiens | |
| 3.4.21.37 | eglin-c | - |
Homo sapiens | |
| 3.4.21.37 | elafin | cationic protease inhibitor of human neutrophil elastase | Homo sapiens | |
| 3.4.21.37 | elasnin | - |
Homo sapiens | |
| 3.4.21.37 | EPI-hNE-4 | potent and specific inhibitor of neutrohil elastase | Homo sapiens | |
| 3.4.21.37 | erythromycin | acts as an alternate substrate neutrophil elastase inhibitor | Homo sapiens | |
| 3.4.21.37 | flurythromycin | inactivator of neutrophil elastase | Homo sapiens | |
| 3.4.21.37 | greglin | fast-acting and tight-binding inhibitor of neutrophil elastase | Homo sapiens | |
| 3.4.21.37 | human monocyte/neutrophil elastase inhibitor | effective inhibition | Homo sapiens | |
| 3.4.21.37 | L-658758 | - |
Homo sapiens | |
| 3.4.21.37 | leupeptin | - |
Homo sapiens | |
| 3.4.21.37 | oleic acid | - |
Homo sapiens | |
| 3.4.21.37 | secretory leukoprotease inhibitor | - |
Homo sapiens | |
| 3.4.21.37 | valinal | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.37 | primary granule | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.37 | coagulation factor V + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | coagulation factor VIII + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | coagulation factor XI + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | coagulation factor XIII + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Collagen type I + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | collagen type II + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Collagen type III + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | collagen type IV + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | collagenase + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | complement factor C3 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | complement factor C5 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | complement receptor + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | elafin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Elastin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Fibrinogen + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Gelatinase + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | gp120 protein + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | immunoglobulin A + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | immunoglobulin G + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | immunoglobulin M + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | intercellular adhesion molecule-1 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | interleukin-1 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | interleukin-2 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | interleukin-6 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | kininogen + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Laminin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | lung surfactant + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | plasminogen + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | platelet IIb/IIIa receptor + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Proteoglycan + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | thrombomodulin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | tissue inhibitor of metalloprotease + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | tissue necrosis factor alpha + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | neutrophil | - |
Homo sapiens | - |
| 3.4.21.37 | serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.37 | coagulation factor V + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | coagulation factor VIII + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | coagulation factor XI + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | coagulation factor XIII + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Collagen type I + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | collagen type II + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Collagen type III + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | collagen type IV + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | collagenase + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | complement factor C3 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | complement factor C5 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | complement receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | elafin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Gelatinase + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | gp120 protein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | immunoglobulin A + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | immunoglobulin G + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | immunoglobulin M + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | intercellular adhesion molecule-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | interleukin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | interleukin-2 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | interleukin-6 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | kininogen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Laminin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | lung surfactant + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | plasminogen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | platelet IIb/IIIa receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Proteoglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | thrombomodulin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | tissue inhibitor of metalloprotease + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | tissue necrosis factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.37 | neutrophil elastase | - |
Homo sapiens |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.21.37 | Homo sapiens | - |
- |
9.4 |
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