Literature summary extracted from

Bukowska, A.; Lendeckel, U.; Krohn, A.; Keilhoff, G.; ten Have, S.; Neumann, K.H.; Goette, A.
Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney (2008), Europace, 10, 1212-1217.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.11	additional information	application of aldosterone, atrial natriuretic peptide, asymmetric dimethylarginine, and angiotensin peptides fail to cause down-regulation of renal neprilysin expression in vitro	Sus scrofa

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.11	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.11	kidney	renal mRNA expression and protein of neprilysin is substantially downregulated during rapid atrial pacing. Irbesartan therapy does not prevent down-regulation of neprilysin. In contrast, TGF-beta1 mRNA expression is up-regulated. Collagen and angiotensin II type 1 receptor expression are not significantly altered by rapid atrial pacing. Application of aldosterone, atrial natriuretic peptide, asymmetric dimethylarginine, and angiotensin peptides fail to cause down-regulation of renal neprilysin expression in vitro	Sus scrofa	-

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Release 2023.1 (January 2023)