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Literature summary extracted from

  • Haase, I.; Mörtl, S.; Köhler, P.; Bacher, A.; Fischer, M.
    Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii (2003), Eur. J. Biochem., 270, 1025-1032.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.78 expression in Escherichia coli Methanocaldococcus jannaschii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.78 0.01
-
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 37°C, pH 7.0 Aquifex aeolicus
2.5.1.78 0.0125
-
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 37°C, pH 7.0 Methanocaldococcus jannaschii
2.5.1.78 0.026
-
L-3,4-dihydroxybutan-2-one 4-phosphate 37°C, pH 7.0 Aquifex aeolicus
2.5.1.78 0.052
-
L-3,4-dihydroxybutan-2-one 4-phosphate 37°C, pH 7.0 Methanocaldococcus jannaschii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.78 15645
-
60 * 15645, the enzyme can form capsids with icosahedral 532 symmetry consisting of 60 subunits, electrospray mass spectrometry Methanocaldococcus jannaschii
2.5.1.78 16000
-
60 * 16000, the enzyme can form capsids with icosahedral 532 symmetry consisting of 60 subunits, SDS-PAGE Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.78 5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate Aquifex aeolicus the enzyme is involved in biosynthesis of riboflavin 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?
2.5.1.78 5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate Methanocaldococcus jannaschii the enzyme is involved in biosynthesis of riboflavin 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.78 Aquifex aeolicus
-
-
-
2.5.1.78 Methanocaldococcus jannaschii Q57751
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.78
-
Aquifex aeolicus
2.5.1.78 recombinant enzyme Methanocaldococcus jannaschii

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.78 0.011
-
37°C, pH 7.0 Methanocaldococcus jannaschii
2.5.1.78 0.031
-
37°C, pH 7.0 Aquifex aeolicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.78 5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate
-
Aquifex aeolicus 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?
2.5.1.78 5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate
-
Methanocaldococcus jannaschii 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?
2.5.1.78 5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate the enzyme is involved in biosynthesis of riboflavin Aquifex aeolicus 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?
2.5.1.78 5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate the enzyme is involved in biosynthesis of riboflavin Methanocaldococcus jannaschii 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
?
2.5.1.78 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one 4-phosphate
-
Aquifex aeolicus 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H2O + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.5.1.78 60-mer 60 * 15645, the enzyme can form capsids with icosahedral 532 symmetry consisting of 60 subunits, electrospray mass spectrometry Methanocaldococcus jannaschii
2.5.1.78 60-mer 60 * 16000, the enzyme can form capsids with icosahedral 532 symmetry consisting of 60 subunits, SDS-PAGE Methanocaldococcus jannaschii

Synonyms

EC Number Synonyms Comment Organism
2.5.1.78 MJ0303
-
Methanocaldococcus jannaschii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.78 37
-
assay at Aquifex aeolicus
2.5.1.78 37
-
assay at Methanocaldococcus jannaschii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.78 7
-
assay at Aquifex aeolicus
2.5.1.78 7
-
assay at Methanocaldococcus jannaschii