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Literature summary extracted from

  • Witola, W.H.; Ben Mamoun, C.
    Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase (2007), Eukaryot. Cell, 6, 1618-1624.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.103 gene PfPMT, expression analysis Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.103 additional information enzyme expression is suppressed by choline Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.103 S-adenosyl-L-methionine + phosphoethanolamine Plasmodium falciparum the phosphoethanolamine methyltransferase is a critical enzyme in the the plant-like serine decarboxylase-phosphoethanolamine methyltransferase, SDPM, pathway, and is downregulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline S-adenosyl-L-homocysteine + methylethanolamine phosphate
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Plasmodium falciparum
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gene PfPMT
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 S-adenosyl-L-methionine + phosphoethanolamine
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Plasmodium falciparum S-adenosyl-L-homocysteine + methylethanolamine phosphate
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?
2.1.1.103 S-adenosyl-L-methionine + phosphoethanolamine the phosphoethanolamine methyltransferase is a critical enzyme in the the plant-like serine decarboxylase-phosphoethanolamine methyltransferase, SDPM, pathway, and is downregulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline Plasmodium falciparum S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 Pfpmt
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Plasmodium falciparum
2.1.1.103 phosphoethanolamine methyltransferase
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Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.103 S-adenosyl-L-methionine
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Plasmodium falciparum