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Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes

De Chaudhuri, S.; Ghosh, P.; Sarma, N.; Majumdar, P.; Sau, T.J.; Basu, S.; Roychoudhury, S.; Ray, K.; Giri, A.K.; Environ. Health Perspect. 116, 501-505 (2008)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.1.1.137
genotyping
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.1.1.137
M287T
naturally occuring mutant
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
additional information
Homo sapiens
As3MT methylates inorganic arsenic and its metabolites
?
-
-
-
2.1.1.137
S-adenosyl-L-methionine + arsenite
Homo sapiens
As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview
S-adenosyl-L-homocysteine + methylarsonate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Homo sapiens
Q9HBK9
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
additional information
As3MT methylates inorganic arsenic and its metabolites
697642
Homo sapiens
?
-
-
-
-
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
697642
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview
697642
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.137
S-adenosyl-L-methionine
-
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.1.1.137
genotyping
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.137
S-adenosyl-L-methionine
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.1.1.137
M287T
naturally occuring mutant
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
additional information
Homo sapiens
As3MT methylates inorganic arsenic and its metabolites
?
-
-
-
2.1.1.137
S-adenosyl-L-methionine + arsenite
Homo sapiens
As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview
S-adenosyl-L-homocysteine + methylarsonate
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
additional information
As3MT methylates inorganic arsenic and its metabolites
697642
Homo sapiens
?
-
-
-
-
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
697642
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview
697642
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?