Literature summary extracted from

Cardoso, L.; Ferreira, S.; Hermes-Lima, M.
Reductive inactivation of yeast glutathione reductase by Fe(II) and NADPH (2008), Comp. Biochem. Physiol. A, 151, 313-321.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.8.1.7	Fe2+	addition of exogenous Fe2+ (but not Fe3+) potentiates NADPH-induced inactivation of glutathione reductase, after a 2 min incubation period, 0.05 mM Fe2+ plus 0.3 mM NADPH induce 57% loss of enzyme activity	Saccharomyces cerevisiae
1.8.1.7	NADPH	58% inhibition at 0.3 mM after 60 min incubation, exogenously added antioxidants including ethanol, dimethylsulfoxide and 2-deoxyribose do not protect glutathione reductase against NADPH-induced inactivation, whilst addition of exogenous Fe2+ (but not Fe3+) potentiates the inactivation, removal of oxygen from the medium leads to increased inhibition of glutathione reductase, whereas pre-incubation of the Fe2+-containing medium for 30 min under normoxic conditions prior to the addition of GR abolishes the enzyme inactivation by NADPH	Saccharomyces cerevisiae

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.7	Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.1.7	glutathione disulfide + NADPH + H+	-	Saccharomyces cerevisiae	glutathione + NADP+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.1.7	glutathione reductase	-	Saccharomyces cerevisiae

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.8.1.7	FAD	-	Saccharomyces cerevisiae
1.8.1.7	NADPH	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)