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Literature summary extracted from

  • Kleer, C.G.; Bloushtain-Qimron, N.; Chen, Y.H.; Carrasco, D.; Hu, M.; Yao, J.; Kraeft, S.K.; Collins, L.C.; Sabel, M.S.; Argani, P.; Gelman, R.; Schnitt, S.J.; Krop, I.E.; Polyak, K.
    Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression (2008), Clin. Cancer Res., 14, 5357-5367.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.22.38 medicine inhibition of CTSK activity may decrease the risk of breast tumor progression Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.38 CTSK expression analysis in healthy, benign tumor and malign tumor breast tissues, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.38 cystatin different types, expression analysis in various cell types isolated from normal and neoplastic breast tissue, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.38 lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.38 additional information Homo sapiens the enzyme may play a role in tumor progression, coculture of CTSK+ fibroblasts enhances the invasion of CTSK-breast tumor epithelial cells, whichis blocked by CTSK inhibitors, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.38 Homo sapiens
-
 gene Ctsk
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.38 breast high expression level Homo sapiens
-
3.4.22.38 breast cancer cell biopsy sites, benign lesions, ductal carcinoma in situ, and invasive breast tumors of different stages. Neither epithelial nor stromal expression of CTSK is significantly associated with recurrence-free or overall survival Homo sapiens
-
3.4.22.38 BT-549 cell
-
 Homo sapiens
-
3.4.22.38 epithelial cell
-
 Homo sapiens
-
3.4.22.38 fibroblast tumor, stromal myofibroblasts, high expression level Homo sapiens
-
3.4.22.38 MDA-MB-435 cell
-
 Homo sapiens
-
3.4.22.38 MDA-MB-468 cell
-
 Homo sapiens
-
3.4.22.38 stromal cell stromal CTSK expression is significantly higher in invasive compared to in situ carcinomas Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.38 additional information the enzyme may play a role in tumor progression, coculture of CTSK+ fibroblasts enhances the invasion of CTSK-breast tumor epithelial cells, whichis blocked by CTSK inhibitors, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.38 CTSK
-
 Homo sapiens