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Literature summary extracted from
- Isocitrate lyase from Mycobacterium tuberculosis promotes survival of Mycobacterium smegmatis within macrophage by suppressing cell apoptosis (2008), Chin. Med. J., 121, 1114-1119.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.1.3.1 | medicine | overexpression of ICL from Mycobacterium smegmatis (MS-ICL) in Mycobacterium smegmatis (MS) does not suppress apoptosis induced in mouse macrophages upon infection by these recombinant bacteria (rMS-pMS-icl) compared to infection by control MS or MS overexpressing ICL from Mycobacterium tuberculosis | Mycolicibacterium smegmatis |
| 4.1.3.1 | medicine | overexpression of ICL from Mycobacterium tuberculosis (MTB-ICL) in Mycobacterium smegmatis (MS) suppresses apoptosis induced in mouse macrophages upon infection by these recombinant bacteria (rMS-pMTB-icl) compared to infection by control MS | Mycobacterium tuberculosis |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.3.1 | from genomic DNA into pQE30 for sequencing and subcloning into Escherichia coli-Mycobacterium shuttle plasmid pUV15(10) for expression as single protein of GFP fusion in Mycobacterium smegmatis also after infection of and phagocytosis by mouse macrophage cell line RAW264.7 | Mycobacterium tuberculosis |
| 4.1.3.1 | from genomic DNA into pQE30 for sequencing and subcloning into Escherichia coli-Mycobacterium shuttle plasmid pUV15(10) for expression in Mycobacterium smegmatis also after infection of and phagocytosis by mouse macrophage cell line RAW264.7, amplified sequence carried non-sense mutation at position 681 (C to G) | Mycolicibacterium smegmatis |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.3.1 | Mycobacterium tuberculosis | - |
H37Rv | - |
| 4.1.3.1 | Mycobacterium tuberculosis H37Rv | - |
H37Rv | - |
| 4.1.3.1 | Mycolicibacterium smegmatis | - |
1-2c | - |
| 4.1.3.1 | Mycolicibacterium smegmatis 1-2c | - |
1-2c | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.3.1 | ICL | - |
Mycolicibacterium smegmatis |
| 4.1.3.1 | ICL | - |
Mycobacterium tuberculosis |
| 4.1.3.1 | isocitrate lyase | - |
Mycolicibacterium smegmatis |
| 4.1.3.1 | isocitrate lyase | - |
Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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