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Literature summary extracted from

  • Stump, B.; Eberle, C.; Schweizer, W.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.; Lentz, D.; Diederich, F.
    Pentafluorosulfanyl as a novel building block for enzyme inhibitors: Trypanothione reductase inhibition and antiprotozoal activities of diarylamines (2009), ChemBioChem, 10, 79-83.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride mixed-type inhibition Trypanosoma cruzi
1.8.1.12 N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride mixed-type inhibition Trypanosoma cruzi
1.8.1.12 N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(trifluoromethyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride competitive inhibition Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Trypanosoma cruzi P28593
-
-

Synonyms

EC Number Synonyms Comment Organism
1.8.1.12 EC 1.6.4.8 formerly Trypanosoma cruzi
1.8.1.12 trypanothione reductase
-
 Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 NADPH
-
 Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.12 0.028
-
 N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride competitive inhibition, at 25°C Trypanosoma cruzi
1.8.1.12 0.084
-
 3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride competitive inhibition, at 25°C Trypanosoma cruzi
1.8.1.12 0.158
-
 3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride uncompetitive inhibition, at 25°C Trypanosoma cruzi
1.8.1.12 0.72
-
 N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride uncompetitive inhibition, at 25°C Trypanosoma cruzi