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Literature summary extracted from

  • Gonzalez-Segura, L.; Mujica-Jimenez, C.; Munoz-Clares, R.A.
    Reaction of the catalytic cysteine of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa with arsenite-BAL and phenylarsine oxide (2009), Chem. Biol. Interact., 178, 64-69.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.1.8 medicine PaBADH could be an antimicrobial target Pseudomonas aeruginosa

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.8 expression in Escherichia coli cells Pseudomonas aeruginosa

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.8 C353A mutant, shows similar inactivation kinetics to the wild-type enzyme Pseudomonas aeruginosa
1.2.1.8 C377A mutant, shows similar inactivation kinetics to the wild-type enzyme Pseudomonas aeruginosa
1.2.1.8 C439A mutant, shows similar inactivation kinetics to the wild-type enzyme Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.8 N-ethylmaleimide
-
 Pseudomonas aeruginosa
1.2.1.8 Phenylarsine oxide PAO Pseudomonas aeruginosa
1.2.1.8 sodium meta-arsenite plus 2,3-dimercaptopropanol arsenite-BAL Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD(P)+ + H2O Pseudomonas aeruginosa
-
 glycine betaine + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.8 Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.8
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD(P)+ + H2O
-
 Pseudomonas aeruginosa glycine betaine + NAD(P)H + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.8 homotetramer
-
 Pseudomonas aeruginosa

Synonyms

EC Number Synonyms Comment Organism
1.2.1.8 BADH
-
 Pseudomonas aeruginosa
1.2.1.8 betaine aldehyde dehydrogenase
-
 Pseudomonas aeruginosa
1.2.1.8 betaine aldehyde:NAD(P)+ oxidoreductase
-
 Pseudomonas aeruginosa
1.2.1.8 PaBADH
-
 Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.8 NAD+ PaBADH uses NAD+ and NADP+ with similar efficiencies Pseudomonas aeruginosa
1.2.1.8 NADP+ PaBADH uses NAD+ and NADP+ with similar efficiencies Pseudomonas aeruginosa