EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.14.17 | drug development | possible enzyme to inhibit for treatment of hypercholesterolemia, but strong side effects (e.g. dermatitis-like toxicity) | Canis lupus familiaris |
2.5.1.21 | medicine | aim of inhibitors in treatment of hypercholesterolemia | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.17 | NB-598 | decrease of LDL and triglyceride levels, dermatitis-like toxicity; decreases LDL and triglyceride levels, strong side effects (e.g. dermatitis-like toxicity) | Canis lupus familiaris | |
1.14.14.17 | NB-598 | decrease of LDL and triglyceride levels, dermatitis-like toxicity | Homo sapiens | |
1.14.14.17 | NB-598 | decrease of LDL and triglyceride levels, dermatitis-like toxicity | Nicotiana sp. | |
2.5.1.21 | BMS 187745 | decrease of cholesterol or LDL | Homo sapiens | |
2.5.1.21 | BMS-188494 | decrease of cholesterol or LDL | Homo sapiens | |
2.5.1.21 | BMS-188494 | no induction of myotoxicity | Rattus norvegicus | |
2.5.1.21 | EP2302 | decrease of cholesterol or LDL | Homo sapiens | |
2.5.1.21 | EP2302 | decrease of cholesterol and triglyceride biosynthesis | Oryctolagus cuniculus | |
2.5.1.21 | EP2306 | decrease of cholesterol or LDL | Homo sapiens | |
2.5.1.21 | EP2306 | decrease of cholesterol and triglyceride biosynthesis | Oryctolagus cuniculus | |
2.5.1.21 | ER-27856 | decrease of cholesterol biosynthesis | Macaca sp. | |
2.5.1.21 | ER-27856 | decrease of cholesterol biosynthesis | Rattus norvegicus | |
2.5.1.21 | ER-28448 | decrease of cholesterol biosynthesis | Macaca sp. | |
2.5.1.21 | ER-28448 | decrease of cholesterol biosynthesis | Rattus norvegicus | |
2.5.1.21 | fenofibrate | - |
Cricetus cricetus | |
2.5.1.21 | lapaquistat | lipid-lowering effect | Callithrix sp. | |
2.5.1.21 | lapaquistat | lipid-lowering effect | Canis lupus familiaris | |
2.5.1.21 | lapaquistat | decrease of cholesterol or LDL | Homo sapiens | |
2.5.1.21 | lapaquistat | lipid-lowering effect | Macaca sp. | |
2.5.1.21 | lapaquistat | lipid-lowering effect | Rattus norvegicus | |
2.5.1.21 | RPR107393 | reduction in plasma cholesterol concentrations | Callithrix sp. | |
2.5.1.21 | RPR107393 | reduction of plasman cholesterol concentrations | Rattus norvegicus | |
2.5.1.21 | squalestatin | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Canis lupus familiaris | |
2.5.1.21 | squalestatin | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Rattus norvegicus | |
2.5.1.21 | YM-53601 | decrease of non-high-density lipoprotein cholesterol | Cavia porcellus | |
2.5.1.21 | YM-53601 | decrease of non-high-density lipoprotein cholesterol | Cricetus cricetus | |
2.5.1.21 | YM-53601 | decrease of non-high-density lipoprotein cholesterol | Macaca sp. | |
2.5.1.21 | zaragozic acid | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Canis lupus familiaris | |
2.5.1.21 | zaragozic acid | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Rattus norvegicus | |
5.4.99.7 | U18666A | produce cataract formation | Metazoa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.5.1.21 | endoplasmic reticulum | - |
Cavia porcellus | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Oryctolagus cuniculus | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Canis lupus familiaris | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Callithrix sp. | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Cricetus cricetus | 5783 | - |
2.5.1.21 | endoplasmic reticulum | - |
Macaca sp. | 5783 | - |
2.5.1.21 | peroxisome | - |
Cavia porcellus | 5777 | - |
2.5.1.21 | peroxisome | - |
Mus musculus | 5777 | - |
2.5.1.21 | peroxisome | - |
Homo sapiens | 5777 | - |
2.5.1.21 | peroxisome | - |
Rattus norvegicus | 5777 | - |
2.5.1.21 | peroxisome | - |
Oryctolagus cuniculus | 5777 | - |
2.5.1.21 | peroxisome | - |
Canis lupus familiaris | 5777 | - |
2.5.1.21 | peroxisome | - |
Callithrix sp. | 5777 | - |
2.5.1.21 | peroxisome | - |
Cricetus cricetus | 5777 | - |
2.5.1.21 | peroxisome | - |
Macaca sp. | 5777 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.21 | Mg2+ | cofactor | Cavia porcellus | |
2.5.1.21 | Mg2+ | cofactor | Mus musculus | |
2.5.1.21 | Mg2+ | cofactor | Homo sapiens | |
2.5.1.21 | Mg2+ | cofactor | Rattus norvegicus | |
2.5.1.21 | Mg2+ | cofactor | Oryctolagus cuniculus | |
2.5.1.21 | Mg2+ | cofactor | Canis lupus familiaris | |
2.5.1.21 | Mg2+ | cofactor | Callithrix sp. | |
2.5.1.21 | Mg2+ | cofactor | Cricetus cricetus | |
2.5.1.21 | Mg2+ | cofactor | Macaca sp. |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.17 | squalene + O2 + AH2 | Homo sapiens | - |
2,3 oxidosqualene + A + H2O | - |
? | |
1.14.14.17 | squalene + O2 + AH2 | Canis lupus familiaris | - |
2,3 oxidosqualene + A + H2O | - |
? | |
1.14.14.17 | squalene + O2 + AH2 | Nicotiana sp. | - |
2,3 oxidosqualene + A + H2O | - |
? | |
5.4.99.7 | (S)-squalene-2,3-epoxide | Metazoa | - |
Lanosterol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.34 | Homo sapiens | - |
- |
- |
1.14.14.17 | Canis lupus familiaris | - |
- |
- |
1.14.14.17 | Homo sapiens | - |
- |
- |
1.14.14.17 | Nicotiana sp. | - |
- |
- |
2.5.1.21 | Callithrix sp. | - |
- |
- |
2.5.1.21 | Canis lupus familiaris | - |
- |
- |
2.5.1.21 | Cavia porcellus | - |
- |
- |
2.5.1.21 | Cricetus cricetus | - |
- |
- |
2.5.1.21 | Homo sapiens | - |
- |
- |
2.5.1.21 | Macaca sp. | - |
- |
- |
2.5.1.21 | Mus musculus | - |
- |
- |
2.5.1.21 | Oryctolagus cuniculus | - |
- |
- |
2.5.1.21 | Rattus norvegicus | - |
- |
- |
5.4.99.7 | Metazoa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.17 | Hep-G2 cell | - |
Homo sapiens | - |
1.14.14.17 | myoblast | - |
Homo sapiens | - |
2.5.1.21 | hepatocyte | - |
Cavia porcellus | - |
2.5.1.21 | hepatocyte | - |
Mus musculus | - |
2.5.1.21 | hepatocyte | - |
Homo sapiens | - |
2.5.1.21 | hepatocyte | - |
Rattus norvegicus | - |
2.5.1.21 | hepatocyte | - |
Oryctolagus cuniculus | - |
2.5.1.21 | hepatocyte | - |
Canis lupus familiaris | - |
2.5.1.21 | hepatocyte | - |
Callithrix sp. | - |
2.5.1.21 | hepatocyte | - |
Cricetus cricetus | - |
2.5.1.21 | hepatocyte | - |
Macaca sp. | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.17 | squalene + O2 + AH2 | - |
Homo sapiens | 2,3 oxidosqualene + A + H2O | - |
? | |
1.14.14.17 | squalene + O2 + AH2 | - |
Canis lupus familiaris | 2,3 oxidosqualene + A + H2O | - |
? | |
1.14.14.17 | squalene + O2 + AH2 | - |
Nicotiana sp. | 2,3 oxidosqualene + A + H2O | - |
? | |
5.4.99.7 | (S)-squalene-2,3-epoxide | - |
Metazoa | Lanosterol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.34 | 3-hydroxymethylglutaryl coenzyme A reductase | - |
Homo sapiens |
1.1.1.34 | HMG-CoA reductase | - |
Homo sapiens |
1.14.14.17 | squalene epoxidase | - |
Homo sapiens |
1.14.14.17 | squalene epoxidase | - |
Canis lupus familiaris |
1.14.14.17 | squalene epoxidase | - |
Nicotiana sp. |
2.5.1.21 | squalene synthase | - |
Cavia porcellus |
2.5.1.21 | squalene synthase | - |
Mus musculus |
2.5.1.21 | squalene synthase | - |
Homo sapiens |
2.5.1.21 | squalene synthase | - |
Rattus norvegicus |
2.5.1.21 | squalene synthase | - |
Oryctolagus cuniculus |
2.5.1.21 | squalene synthase | - |
Canis lupus familiaris |
2.5.1.21 | squalene synthase | - |
Callithrix sp. |
2.5.1.21 | squalene synthase | - |
Cricetus cricetus |
2.5.1.21 | squalene synthase | - |
Macaca sp. |
5.4.99.7 | 2,3 oxidosqualene:lanosterol cyclase | - |
Metazoa |
5.4.99.7 | Oxidosqualene cyclase | - |
Metazoa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.21 | NADH | - |
Cavia porcellus | |
2.5.1.21 | NADH | - |
Mus musculus | |
2.5.1.21 | NADH | - |
Homo sapiens | |
2.5.1.21 | NADH | - |
Rattus norvegicus | |
2.5.1.21 | NADH | - |
Oryctolagus cuniculus | |
2.5.1.21 | NADH | - |
Canis lupus familiaris | |
2.5.1.21 | NADH | - |
Callithrix sp. | |
2.5.1.21 | NADH | - |
Cricetus cricetus | |
2.5.1.21 | NADH | - |
Macaca sp. | |
2.5.1.21 | NADPH | - |
Cavia porcellus | |
2.5.1.21 | NADPH | - |
Mus musculus | |
2.5.1.21 | NADPH | - |
Homo sapiens | |
2.5.1.21 | NADPH | - |
Rattus norvegicus | |
2.5.1.21 | NADPH | - |
Oryctolagus cuniculus | |
2.5.1.21 | NADPH | - |
Canis lupus familiaris | |
2.5.1.21 | NADPH | - |
Callithrix sp. | |
2.5.1.21 | NADPH | - |
Cricetus cricetus | |
2.5.1.21 | NADPH | - |
Macaca sp. |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.34 | metabolism | part of cholesterol synthesis pathway | Homo sapiens |
1.14.14.17 | metabolism | part of cholesterol synthesis pathway | Homo sapiens |
1.14.14.17 | metabolism | part of cholesterol synthesis pathway | Canis lupus familiaris |
1.14.14.17 | metabolism | part of cholesterol synthesis pathway | Nicotiana sp. |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Cavia porcellus |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Mus musculus |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Homo sapiens |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Rattus norvegicus |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Oryctolagus cuniculus |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Canis lupus familiaris |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Callithrix sp. |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Cricetus cricetus |
2.5.1.21 | metabolism | part of cholesterol synthesis pathway | Macaca sp. |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Cavia porcellus |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Mus musculus |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Rattus norvegicus |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Oryctolagus cuniculus |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Canis lupus familiaris |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Callithrix sp. |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Cricetus cricetus |
2.5.1.21 | physiological function | influence on regulation of cholesterol metabolism | Macaca sp. |
5.4.99.7 | metabolism | part of cholesterol synthesis pathway | Metazoa |