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Literature summary extracted from

  • Tu, C.; Ortega-Cava, C.F.; Chen, G.; Fernandes, N.D.; Cavallo-Medved, D.; Sloane, B.F.; Band, V.; Band, H.
    Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts (2008), Cancer Res., 68, 9147-9156.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.1 additional information bafilomycin A1 induces lysosome-associated podosome-like structures and promotes degradation of extracellular gelatin Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 bafilomycin
-
 Mus musculus
3.4.22.1 E64c
-
 Mus musculus
3.4.22.1 E64d
-
 Mus musculus
3.4.22.1 N-(L-3-trans-propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline i.e. CA074, a cathepsin B-selective inhibitor Mus musculus
3.4.22.1 N-(L-3-trans-propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester i.e. CA074Me, a cathepsin B-selective inhibitor Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.1 lysosome lysosomes localized at podosomes Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 Gelatin + H2O Mus musculus
-
 ?
-
 ?
3.4.22.1 additional information Mus musculus cathepsin B belongs to the lysosomal cysteine cathepsins, a third major class of matrix-degrading enzymes involved in tumor invasion and tissue remodeling. Cathepsin B is involved in matrix degradation at podosomes, cysteine protease inhibitors reduce matrix degradation and invasion in vitro ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 fibroblast protease v-Src-transformed fibroblasts Mus musculus
-
3.4.22.1 NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.22.1 additional information cathepsin B belongs to the lysosomal cysteine cathepsins, a third major class of matrix-degrading enzymes involved in tumor invasion and tissue remodeling. Cathepsin B is involved in matrix degradation at podosomes, cysteine protease inhibitors reduce matrix degradation and invasion in vitro Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.1 More cathepsin B belongs to the class of lysosomal cysteine cathepsins Mus musculus