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Literature summary extracted from

  • Balasubramanian, S.; Verner, E.; Buggy, J.J.
    Isoform-specific histone deacetylase inhibitors: The next step? (2009), Cancer Lett., 280, 211-221.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.98 medicine HDAC inhibitors have attracted a great deal of interest as drug targets in recent years Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 (2E)-N-hydroxy-3-naphthalen-1-ylprop-2-enamide HDAC8-selective inhibitor Homo sapiens
3.5.1.98 2,2,2-trifluoro-1-[5-(3-methyl-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone HDAC4-selective inhibitor Homo sapiens
3.5.1.98 Butyrate class I-selective HDAC inhibitor Homo sapiens
3.5.1.98 ITF-2357 broad-spectrum or pan-HDAC inhibitor Homo sapiens
3.5.1.98 JNJ-26481585 broad-spectrum or pan-HDAC inhibitor Homo sapiens
3.5.1.98 LBH-589 panobinostat, broad-spectrum or pan-HDAC inhibitor Homo sapiens
3.5.1.98 MGCD-0103 mocetinostat dihydrobromide, class I-selective HDAC inhibitor Homo sapiens
3.5.1.98 MS-275 SNDX-275, entinostat, class I-selective HDAC inhibitor Homo sapiens
3.5.1.98 N-hydroxy-1-methyl-indole-6-carboxamide HDAC8-selective inhibitor Homo sapiens
3.5.1.98 N-hydroxynaphthalene-1-carboxamide HDAC8-selective inhibitor Homo sapiens
3.5.1.98 PCI-24781 broad-spectrum or pan-HDAC inhibitor Homo sapiens
3.5.1.98 PCI-34051 HDAC8-selective inhibitor Homo sapiens
3.5.1.98 PXD-101 belinostat, broad-spectrum or pan-HDAC inhibitor Homo sapiens
3.5.1.98 romidepsin FK-228, FR901228, depsipeptide, class I-selective HDAC inhibitor Homo sapiens
3.5.1.98 suberoylanilide hydroxamic acid SAHA, vorinostat, zolinza, broad-spectrum or pan-HDAC inhibitor Homo sapiens
3.5.1.98 tubacin HDAC6-selective inhibitor Homo sapiens
3.5.1.98 Valproate class I-selective HDAC inhibitor Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.98 Zn2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC
-
 Homo sapiens
3.5.1.98 histone deacetylase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.98 0.000015
-
 PCI-34051 HDAC8 inhibition Homo sapiens
3.5.1.98 0.0007
-
 (2E)-N-hydroxy-3-naphthalen-1-ylprop-2-enamide HDAC8 inhibition Homo sapiens
3.5.1.98 0.0013
-
 N-hydroxy-1-methyl-indole-6-carboxamide HDAC8 inhibition Homo sapiens
3.5.1.98 0.0085
-
 N-hydroxy-1-methyl-indole-6-carboxamide HDAC1 inhibition Homo sapiens
3.5.1.98 0.014
-
 N-hydroxynaphthalene-1-carboxamide HDAC8 inhibition Homo sapiens