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Literature summary extracted from

  • Ishii, N.; Umemura, K.; Miyazaki, K.
    Supramolecular complex formation and crystallization of isocitrate dehydrogenase from Thermus thermophilus HB8: preliminary studies with X-ray crystallography and atomic force microscopy (2008), Biosci. Biotechnol. Biochem., 72, 2369-2376.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.42 expressed in Escherichia coli strain MV1190 Thermus thermophilus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.42 sitting and hanging drop vapour diffusion method, using 100 mM cacodylate and 1.4 M sodium acetate, 10 mM citric acid , and 10 mM MnCl2, at pH 6.5-7.8 and 25°C Thermus thermophilus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.42 54200
-
calculated from amino acid sequence Thermus thermophilus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Thermus thermophilus P33197
-
-
1.1.1.42 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 P33197
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.42
-
Thermus thermophilus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 (2R,3S)-isocitrate + NADP+
-
Thermus thermophilus 2-oxoglutarate + CO2 + NADPH
-
?
1.1.1.42 (2R,3S)-isocitrate + NADP+
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579 2-oxoglutarate + CO2 + NADPH
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 ICDH
-
Thermus thermophilus
1.1.1.42 NAD+-dependent isocitrate dehydrogenase
-
Thermus thermophilus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
Thermus thermophilus