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Literature summary extracted from

  • Li, X.; Wang, Y.; Wu, J.; Li, Y.; Wang, Q.; Xu, W.
    Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II) (2009), Bioorg. Med. Chem., 17, 3061-3071.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 (4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-3-methyl-1-oxobutan-2-ylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(3-(4-fluorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (4S,E)-5-(1,4-dimethoxy-1,4-dioxobutan-2-ylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(2-fluorophenyl)pentanediamide
-
Sus scrofa
3.4.11.2 (S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(4-fluorophenyl)pentanediamide
-
Sus scrofa
3.4.11.2 (S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-di-p-tolylpentanediamide
-
Sus scrofa
3.4.11.2 (S,E)-2-[3-(3,4-dimethoxyphenyl)acrylamido]-N1,N5-[(R)-1,4-dimethoxy-1,4-dioxobutan]pentanediamide
-
Sus scrofa
3.4.11.2 (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-fluorophenylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-methoxy-2-oxoethylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(4-fluorophenylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(ethylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(isopropylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(methylamino)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxo-5-(propylamino)pentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-5-(2-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-5-(3,5-difluorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-5-(3-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-5-(4-bromophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-5-(4-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-5-(benzylamino)-4-(3-(3,4-dimethoxyphenyl)-acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-5-(p-toluidino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
Sus scrofa
3.4.11.2 (S,E)-N1,N5-bis(3,5-difluorophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
-
Sus scrofa
3.4.11.2 (S,E)-N1,N5-bis(4-bromophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
-
Sus scrofa
3.4.11.2 (S,E)-N1,N5-bis(4-chlorophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
-
Sus scrofa
3.4.11.2 bestatin
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 microsome
-
Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.2 Zn2+ dependent on Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-p-nitroanilide + H2O
-
Sus scrofa L-Leu + p-nitroaniline
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
Sus scrofa
3.4.11.2 APN
-
Sus scrofa
3.4.11.2 CD13
-
Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.2 0.0131
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa bestatin
3.4.11.2 0.0207
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-5-(p-toluidino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
3.4.11.2 0.0234
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(4-fluorophenylamino)-5-oxopentanoic acid
3.4.11.2 0.0345
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-5-(4-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
3.4.11.2 0.0383
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-5-(2-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
3.4.11.2 0.0437
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(3-(4-fluorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
3.4.11.2 0.0504
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-methoxy-2-oxoethylamino)-5-oxopentanoic acid
3.4.11.2 0.0551
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
3.4.11.2 0.0568
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-fluorophenylamino)-5-oxopentanoic acid
3.4.11.2 0.0581
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-5-(4-bromophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
3.4.11.2 0.0605
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (4S,E)-5-(1,4-dimethoxy-1,4-dioxobutan-2-ylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
3.4.11.2 0.0692
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-3-methyl-1-oxobutan-2-ylamino)-5-oxopentanoic acid
3.4.11.2 0.0805
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-5-(3-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
3.4.11.2 0.0986
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-5-(3,5-difluorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
3.4.11.2 0.1258
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(methylamino)-5-oxopentanoic acid
3.4.11.2 0.1776
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-5-(benzylamino)-4-(3-(3,4-dimethoxyphenyl)-acrylamido)-5-oxopentanoic acid
3.4.11.2 0.1843
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(ethylamino)-5-oxopentanoic acid
3.4.11.2 0.2072
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(isopropylamino)-5-oxopentanoic acid
3.4.11.2 0.2375
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxo-5-(propylamino)pentanoic acid
3.4.11.2 0.3347
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-di-p-tolylpentanediamide
3.4.11.2 0.3713
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(4-fluorophenyl)pentanediamide
3.4.11.2 0.4052
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-N1,N5-bis(4-chlorophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
3.4.11.2 0.4052
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(2-fluorophenyl)pentanediamide
3.4.11.2 0.5776
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-N1,N5-bis(4-bromophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
3.4.11.2 2.132
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (S,E)-2-[3-(3,4-dimethoxyphenyl)acrylamido]-N1,N5-[(R)-1,4-dimethoxy-1,4-dioxobutan]pentanediamide