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Literature summary extracted from

  • Zaheer-ul-Haq, K.; Lodhi, M.A.; Ahmad Nawaz, S.; Iqbal, S.; Mohammed Khan, K.; Rode, B.M.; Atta-ur-Rahman, B.M.; Choudhary, M.I.
    3D-QSAR CoMFA studies on bis-coumarine analogues as urease inhibitors: a strategic design in anti-urease agents (2008), Bioorg. Med. Chem., 16, 3456-3461.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.5 3,3'-(1H-indol-3-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-(1H-pyrrol-2-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-(2-phenylpropane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-(2E)-but-2-ene-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-(3-phenylpropane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-(naphthalen-1-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-(pyridin-3-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-(pyridin-4-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-butane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-ethane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-hexane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-pentane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(1E)-1-phenylprop-1-ene-3,3-diyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(2-bromophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(2-chlorophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(2-methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3,4,5-trimethoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3,4-dimethoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3-aminophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3-chlorophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3-ethoxy-4-hydroxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3-hydroxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3-methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(3-nitrophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(4-hydroxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(4-methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[(4-nitrophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[[4-(1-methylethyl)phenyl]methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis
3.5.1.5 3,3'-[[4-(dimethylamino)phenyl]methanediyl]bis(4-hydroxy-2H-chromen-2-one)
-
 Canavalia ensiformis

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.5 Canavalia ensiformis
-
 Jack bean
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.5 urea + H2O
-
 Canavalia ensiformis CO2 + 2 NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.5 urease
-
 Canavalia ensiformis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.5 additional information
-
 pIC50: 4.04 Canavalia ensiformis 3,3'-[(3-ethoxy-4-hydroxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.06 Canavalia ensiformis 3,3'-hexane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.07 Canavalia ensiformis 3,3'-(naphthalen-1-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.07 Canavalia ensiformis 3,3'-[(2-chlorophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.08 Canavalia ensiformis 3,3'-[[4-(1-methylethyl)phenyl]methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.08 Canavalia ensiformis 3,3'-[(2-methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.08 Canavalia ensiformis 3,3'-[(3,4,5-trimethoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.09 Canavalia ensiformis 3,3'-[[4-(dimethylamino)phenyl]methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.09 Canavalia ensiformis 3,3'-[(3-nitrophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.10 Canavalia ensiformis 3,3'-[(3,4-dimethoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.12 Canavalia ensiformis 3,3'-[(3-aminophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.13 Canavalia ensiformis 3,3'-[(4-hydroxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.13 Canavalia ensiformis 3,3'-[(2-bromophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.13 Canavalia ensiformis 3,3'-[(3-chlorophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.14 Canavalia ensiformis 3,3'-[(3-hydroxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.15 Canavalia ensiformis 3,3'-[(4-nitrophenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.17 Canavalia ensiformis 3,3'-butane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.17 Canavalia ensiformis 3,3'-(3-phenylpropane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.19 Canavalia ensiformis 3,3'-pentane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.20 Canavalia ensiformis 3,3'-ethane-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.21 Canavalia ensiformis 3,3'-(1H-indol-3-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.22 Canavalia ensiformis 3,3'-[(4-methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.22 Canavalia ensiformis 3,3'-[(1E)-1-phenylprop-1-ene-3,3-diyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.23 Canavalia ensiformis 3,3'-(pyridin-4-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.25 Canavalia ensiformis 3,3'-[(3-methoxyphenyl)methanediyl]bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.28 Canavalia ensiformis 3,3'-(2-phenylpropane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.33 Canavalia ensiformis 3,3'-(1H-pyrrol-2-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.36 Canavalia ensiformis 3,3'-(2E)-but-2-ene-1,1-diylbis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.45 Canavalia ensiformis 3,3'-(pyridin-3-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
3.5.1.5 additional information
-
 pIC50: 4.82 Canavalia ensiformis 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one)