BRENDA - Enzyme Database

Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols

Chethan, S.; Dharmesh, S.M.; Malleshi, N.G.; Bioorg. Med. Chem. 16, 10085-10090 (2008)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.21
4-hydroxybenzoic acid
-
Homo sapiens
1.1.1.21
ferulic acid
-
Homo sapiens
1.1.1.21
gallic acid
-
Homo sapiens
1.1.1.21
p-catechuic acid
-
Homo sapiens
1.1.1.21
p-coumaric acid
-
Homo sapiens
1.1.1.21
quercetin
-
Homo sapiens
1.1.1.21
syringic acid
-
Homo sapiens
1.1.1.21
trans-cinnamic acid
-
Homo sapiens
1.1.1.21
vanillic acid
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.21
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.21
lens
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.21
D-glucose + NADPH + H+
-
696708
Homo sapiens
sorbitol + NADP+
-
-
-
?
1.1.1.21
DL-glyceraldehyde + NADPH + H+
-
696708
Homo sapiens
glycerol + NADP+
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.21
NADPH
-
Homo sapiens
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.1.1.21
additional information
-
gallic acid IC50: 0.0973 mg/ml, p-coumaric acid IC50: 0.1623 mg/ml, syringic acid IC50: 0.1721 mg/ml, trans-cinnamic acid IC50: 0.0681 mg/ml, p-catechuic acid IC50: 0.0427 mg/ml, quercetin IC50: 0.02523 mg/ml (in 50 mM sodium potassium phosphate buffer (pH 6.0) containing 5 mM beta-mercaptoethanol, 0.7 M NADPH, 0.4 M Li2SO4, and 2.5 mM of DL-glyceraldehyde)
Homo sapiens
additional information
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.21
NADPH
-
Homo sapiens
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.1.1.21
additional information
-
gallic acid IC50: 0.0973 mg/ml, p-coumaric acid IC50: 0.1623 mg/ml, syringic acid IC50: 0.1721 mg/ml, trans-cinnamic acid IC50: 0.0681 mg/ml, p-catechuic acid IC50: 0.0427 mg/ml, quercetin IC50: 0.02523 mg/ml (in 50 mM sodium potassium phosphate buffer (pH 6.0) containing 5 mM beta-mercaptoethanol, 0.7 M NADPH, 0.4 M Li2SO4, and 2.5 mM of DL-glyceraldehyde)
Homo sapiens
additional information
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.21
4-hydroxybenzoic acid
-
Homo sapiens
1.1.1.21
ferulic acid
-
Homo sapiens
1.1.1.21
gallic acid
-
Homo sapiens
1.1.1.21
p-catechuic acid
-
Homo sapiens
1.1.1.21
p-coumaric acid
-
Homo sapiens
1.1.1.21
quercetin
-
Homo sapiens
1.1.1.21
syringic acid
-
Homo sapiens
1.1.1.21
trans-cinnamic acid
-
Homo sapiens
1.1.1.21
vanillic acid
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.21
lens
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.21
D-glucose + NADPH + H+
-
696708
Homo sapiens
sorbitol + NADP+
-
-
-
?
1.1.1.21
DL-glyceraldehyde + NADPH + H+
-
696708
Homo sapiens
glycerol + NADP+
-
-
-
?