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Literature summary extracted from

  • Sentuerk, M.; Talaz, O.; Ekinci, D.; Cavdar, H.; Kuefrevio?lu, O.I.
    In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates (2009), Bioorg. Med. Chem. Lett., 19, 3661-3663.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 (1R(S),2R(S),3S(R),4S(R))-2,3-dihydroxycyclo-hexane-1,4-diyl dinitrate non-competitive inhibition Homo sapiens
1.8.1.7 (1R(S),2R(S),4R(S),5R(S))-2,5-dihydroxycyclo-hexane-1,4-diyl dinitrate non-competitive inhibition Homo sapiens
1.8.1.7 (1S(R),2S(R),5R(S),6R(S))-5-bromo-9-oxabicyclo[4.2.1] nonan-2-yl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 (1S(R),3S(R),4S(R),6S(R))-4,6-dihydroxycyclo-hexane-1,3-diyl dinitrate non-competitive inhibition Homo sapiens
1.8.1.7 (2R(S),7R(S))-7-hydroxybicyclo[2.2.1]heptan-2-yl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 (2S(R),7R(S))-7-hydroxybicyclo[2.2.1] heptan-2-yl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 (9R(S))-hydroxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2R(S)-yl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 trans-(1S(R),2S(R))-2-hydroxycyclooctyl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 trans-(1S(R),6S(R))-6-hydroxycyclohex-3-enyl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 trans-(1S(R),8S(R),Z)-8-hydroxycyclooct-4-enyl nitrate non-competitive inhibition Homo sapiens
1.8.1.7 trans-(R(S))-2-hydroxy-1-phenylethyl nitrate non-competitive inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 EC 1.6.4.2 formerly Homo sapiens
1.8.1.7 glutathione reductase
-
 Homo sapiens
1.8.1.7 NADPH: oxidized glutathione oxidoreductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
 Homo sapiens
1.8.1.7 NADPH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.7 0.0117
-
 (2R(S),7R(S))-7-hydroxybicyclo[2.2.1]heptan-2-yl nitrate
-
 Homo sapiens
1.8.1.7 0.0131
-
 (2S(R),7R(S))-7-hydroxybicyclo[2.2.1] heptan-2-yl nitrate
-
 Homo sapiens
1.8.1.7 0.0174
-
 (1R(S),2R(S),3S(R),4S(R))-2,3-dihydroxycyclo-hexane-1,4-diyl dinitrate
-
 Homo sapiens
1.8.1.7 0.0179
-
 (1S(R),3S(R),4S(R),6S(R))-4,6-dihydroxycyclo-hexane-1,3-diyl dinitrate
-
 Homo sapiens
1.8.1.7 0.0184
-
 (1R(S),2R(S),4R(S),5R(S))-2,5-dihydroxycyclo-hexane-1,4-diyl dinitrate
-
 Homo sapiens
1.8.1.7 0.0188
-
 (9R(S))-hydroxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2R(S)-yl nitrate
-
 Homo sapiens
1.8.1.7 0.0215
-
 (1S(R),2S(R),5R(S),6R(S))-5-bromo-9-oxabicyclo[4.2.1] nonan-2-yl nitrate
-
 Homo sapiens
1.8.1.7 0.0219
-
 trans-(1S(R),2S(R))-2-hydroxycyclooctyl nitrate
-
 Homo sapiens
1.8.1.7 0.0256
-
 trans-(R(S))-2-hydroxy-1-phenylethyl nitrate
-
 Homo sapiens
1.8.1.7 0.0351
-
 trans-(1S(R),6S(R))-6-hydroxycyclohex-3-enyl nitrate
-
 Homo sapiens
1.8.1.7 0.0437
-
 trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate
-
 Homo sapiens
1.8.1.7 0.0443
-
 trans-(1S(R),8S(R),Z)-8-hydroxycyclooct-4-enyl nitrate
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.00681
-
-
 Homo sapiens (2R(S),7R(S))-7-hydroxybicyclo[2.2.1]heptan-2-yl nitrate
1.8.1.7 0.00713
-
-
 Homo sapiens (2S(R),7R(S))-7-hydroxybicyclo[2.2.1] heptan-2-yl nitrate
1.8.1.7 0.00717
-
-
 Homo sapiens (1R(S),2R(S),3S(R),4S(R))-2,3-dihydroxycyclo-hexane-1,4-diyl dinitrate
1.8.1.7 0.0081
-
-
 Homo sapiens (1S(R),3S(R),4S(R),6S(R))-4,6-dihydroxycyclo-hexane-1,3-diyl dinitrate
1.8.1.7 0.00871
-
-
 Homo sapiens (1R(S),2R(S),4R(S),5R(S))-2,5-dihydroxycyclo-hexane-1,4-diyl dinitrate
1.8.1.7 0.0103
-
-
 Homo sapiens (9R(S))-hydroxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2R(S)-yl nitrate
1.8.1.7 0.011
-
-
 Homo sapiens (1S(R),2S(R),5R(S),6R(S))-5-bromo-9-oxabicyclo[4.2.1] nonan-2-yl nitrate
1.8.1.7 0.0142
-
-
 Homo sapiens trans-(1S(R),2S(R))-2-hydroxycyclooctyl nitrate
1.8.1.7 0.016
-
-
 Homo sapiens trans-(R(S))-2-hydroxy-1-phenylethyl nitrate
1.8.1.7 0.021
-
-
 Homo sapiens trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate
1.8.1.7 0.023
-
-
 Homo sapiens trans-(1S(R),6S(R))-6-hydroxycyclohex-3-enyl nitrate
1.8.1.7 0.029
-
-
 Homo sapiens trans-(1S(R),8S(R),Z)-8-hydroxycyclooct-4-enyl nitrate