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Literature summary extracted from

  • Isik, S.; Kockar, F.; Arslan, O.; Guler, O.O.; Innocenti, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions (2008), Bioorg. Med. Chem. Lett., 18, 6327-6331.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide Saccharomyces cerevisiae
4.2.1.1 azide weak inhibition Saccharomyces cerevisiae
4.2.1.1 bicarbonate
-
 Saccharomyces cerevisiae
4.2.1.1 bisulfite
-
 Saccharomyces cerevisiae
4.2.1.1 bromide strong inhibition Saccharomyces cerevisiae
4.2.1.1 Carbonate
-
 Saccharomyces cerevisiae
4.2.1.1 chloride
-
 Saccharomyces cerevisiae
4.2.1.1 Cyanate weak inhibition Saccharomyces cerevisiae
4.2.1.1 cyanide weak inhibition Saccharomyces cerevisiae
4.2.1.1 fluoride
-
 Saccharomyces cerevisiae
4.2.1.1 hydrogen sulfide
-
 Saccharomyces cerevisiae
4.2.1.1 Iodide strong inhibition Saccharomyces cerevisiae
4.2.1.1 additional information not inhibited by perchlorate Saccharomyces cerevisiae
4.2.1.1 nitrate
-
 Saccharomyces cerevisiae
4.2.1.1 nitrite
-
 Saccharomyces cerevisiae
4.2.1.1 phenylarsonic acid
-
 Saccharomyces cerevisiae
4.2.1.1 phenylboronic acid weak inhibition Saccharomyces cerevisiae
4.2.1.1 sulfamate
-
 Saccharomyces cerevisiae
4.2.1.1 sulfamide strong inhibition Saccharomyces cerevisiae
4.2.1.1 sulfate
-
 Saccharomyces cerevisiae
4.2.1.1 thiocyanate weak inhibition Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Saccharomyces cerevisiae H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 beta-carbonic anhydrase
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 940000
-
 CO2 at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000082
-
 acetazolamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.0087
-
 sulfamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.0103
-
 Iodide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.0108
-
 bromide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.33
-
 hydrogen sulfide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.33
-
 bisulfite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.33
-
 sulfamate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.4
-
 phenylarsonic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.46
-
 nitrate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.58
-
 sulfate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.76
-
 Carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.78
-
 bicarbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 0.85
-
 chloride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 2.85
-
 fluoride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 16.8
-
 cyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 27.9
-
 azide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 31.7
-
 Cyanate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 38.2
-
 phenylboronic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae
4.2.1.1 55.6
-
 thiocyanate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4- Saccharomyces cerevisiae