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Literature summary extracted from

  • Li, Y.; Qian, Z.J.; Kim, S.K.
    Cathepsin B inhibitory activities of three new phthalate derivatives isolated from seahorse, Hippocampus Kuda Bleeker (2008), Bioorg. Med. Chem. Lett., 18, 6130-6134.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.1 medicine cathepsin B inhibitors are expected to be useful for the treatment of inflammatory joint disease, invasion of cancer, and other diseases related to cathepsin B disorder Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 2,12-diethyl-11-methylhexadecyl 2-ethyl-11-methylhexadecyl phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
3.4.22.1 2-ethyldecyl 2-ethylundecyl phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
3.4.22.1 bis(2-ethyldodecyl) phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
3.4.22.1 bis(2-ethylheptyl) phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
3.4.22.1 cystatin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 additional information Rattus norvegicus effective inhibition of cathepsin B can decrease the severity of joint inflammation and to reduce the destruction of particular tissues in the rat model of antigen adjuvant-induced arthritis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 additional information effective inhibition of cathepsin B can decrease the severity of joint inflammation and to reduce the destruction of particular tissues in the rat model of antigen adjuvant-induced arthritis Rattus norvegicus ?
-
 ?
3.4.22.1 additional information cathepsin B is a lysosomal cysteine protease, a unique cysteine member showing dual roles as both endopeptidase and exopeptidase activities due to the presence of the occluding loop in structure Rattus norvegicus ?
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.1 0.13
-
-
 Rattus norvegicus 2,12-diethyl-11-methylhexadecyl 2-ethyl-11-methylhexadecyl phthalate
3.4.22.1 0.18
-
-
 Rattus norvegicus bis(2-ethyldodecyl) phthalate
3.4.22.1 0.21
-
-
 Rattus norvegicus 2-ethyldecyl 2-ethylundecyl phthalate
3.4.22.1 0.29
-
-
 Rattus norvegicus bis(2-ethylheptyl) phthalate