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Literature summary extracted from

  • Innocenti, A.; Muehlschlegel, F.A.; Hall, R.A.; Steegborn, C.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions (2008), Bioorg. Med. Chem. Lett., 18, 5066-5070.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide
-
 Candida albicans
4.2.1.1 acetazolamide i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide Cryptococcus neoformans
4.2.1.1 azide
-
 Candida albicans
4.2.1.1 azide
-
 Cryptococcus neoformans
4.2.1.1 bromide
-
 Candida albicans
4.2.1.1 bromide
-
 Cryptococcus neoformans
4.2.1.1 Carbonate potent inhibitor Candida albicans
4.2.1.1 Carbonate
-
 Cryptococcus neoformans
4.2.1.1 chloride
-
 Candida albicans
4.2.1.1 chloride
-
 Cryptococcus neoformans
4.2.1.1 cyanide potent inhibitor Candida albicans
4.2.1.1 cyanide weak inhibitor Cryptococcus neoformans
4.2.1.1 fluoride
-
 Candida albicans
4.2.1.1 fluoride
-
 Cryptococcus neoformans
4.2.1.1 hydrogen carbonate
-
 Candida albicans
4.2.1.1 hydrogen carbonate
-
 Cryptococcus neoformans
4.2.1.1 hydrogen sulfide
-
 Candida albicans
4.2.1.1 hydrogen sulfide best Can2 anion inhibitor Cryptococcus neoformans
4.2.1.1 hydrogen sulfite
-
 Candida albicans
4.2.1.1 hydrogen sulfite
-
 Cryptococcus neoformans
4.2.1.1 Iodide
-
 Candida albicans
4.2.1.1 Iodide worst Can2 anion inhibitor Cryptococcus neoformans
4.2.1.1 isocyanide
-
 Candida albicans
4.2.1.1 isocyanide
-
 Cryptococcus neoformans
4.2.1.1 additional information perchlorate is not an inhibitor in concentrations up to 200 mM Candida albicans
4.2.1.1 additional information Can2 is not inhibited by perchlorate Cryptococcus neoformans
4.2.1.1 nitrate
-
 Candida albicans
4.2.1.1 nitrate
-
 Cryptococcus neoformans
4.2.1.1 nitrite
-
 Candida albicans
4.2.1.1 nitrite
-
 Cryptococcus neoformans
4.2.1.1 phenyl arsonic acid weak Nce103 inhibitor Candida albicans
4.2.1.1 phenyl arsonic acid
-
 Cryptococcus neoformans
4.2.1.1 phenyl boronic acid weak Nce103 inhibitor Candida albicans
4.2.1.1 phenyl boronic acid
-
 Cryptococcus neoformans
4.2.1.1 sulfamic acid
-
 Candida albicans
4.2.1.1 sulfamic acid weak inhibitor Cryptococcus neoformans
4.2.1.1 sulfamide
-
 Candida albicans
4.2.1.1 sulfamide
-
 Cryptococcus neoformans
4.2.1.1 sulfate weak Nce103 inhibitor Candida albicans
4.2.1.1 sulfate
-
 Cryptococcus neoformans
4.2.1.1 Thiocyanide
-
 Candida albicans
4.2.1.1 Thiocyanide
-
 Cryptococcus neoformans

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Candida albicans
-
-
-
4.2.1.1 Cryptococcus neoformans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Candida albicans H2CO3
-
 r
4.2.1.1 CO2 + H2O
-
 Cryptococcus neoformans H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 beta-carbonic anhydrase
-
 Candida albicans
4.2.1.1 beta-carbonic anhydrase
-
 Cryptococcus neoformans
4.2.1.1 Can2
-
 Cryptococcus neoformans
4.2.1.1 Nce103
-
 Candida albicans

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 390000
-
 CO2 at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 800000
-
 CO2 at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.0000105
-
 acetazolamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.000132
-
 acetazolamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.01
-
 Carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.011
-
 cyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.3
-
 sulfamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.37
-
 hydrogen sulfide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.52
-
 azide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.53
-
 nitrite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.54
-
 hydrogen sulfite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.6
-
 hydrogen sulfide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.6
-
 Carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.62
-
 hydrogen carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.65
-
 Thiocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.69
-
 nitrate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.69
-
 fluoride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.7
-
 sulfamic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.71
-
 hydrogen sulfite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.73
-
 azide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.75
-
 hydrogen carbonate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.81
-
 phenyl boronic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.85
-
 chloride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.86
-
 sulfate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.86
-
 fluoride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.87
-
 phenyl arsonic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.92
-
 chloride at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.92
-
 nitrate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.94
-
 bromide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 0.94
-
 Thiocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.96
-
 nitrite at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 0.99
-
 sulfamide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 1
-
 bromide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 1.01
-
 isocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 1.11
-
 Iodide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 1.18
-
 isocyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 1.4
-
 Iodide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 8.22
-
 sulfamic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 13.56
-
 cyanide at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 14.15
-
 sulfate at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 30.84
-
 phenyl arsonic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 30.85
-
 phenyl boronic acid at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans