Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Le Mellay-Hamon, V.; Criton, M.
    Phenylethylamide and phenylmethylamide derivatives as new tyrosinase inhibitors (2009), Biol. Pharm. Bull., 32, 301-303.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 (2E)-3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxybenzyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dihydroxyphenyl)ethyl]prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-(4-chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-(4-hydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide strong tyrosinase inhibitory potential Agaricus bisporus
1.14.18.1 (2E)-3-(4-methoxyphenyl)-N-(1-phenylethyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-(4-methoxyphenyl)-N-(2-phenylethyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-phenyl-N-(1-phenylethyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-3-phenyl-N-(2-phenylethyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-N-(3,4-dihydroxybenzyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-N-(4-chlorobenzyl)-3-phenylprop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-N-benzyl-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-N-benzyl-3-(4-hydroxyphenyl)prop-2-enamide strong tyrosinase inhibitory potential Agaricus bisporus
1.14.18.1 (2E)-N-benzyl-3-(4-methoxyphenyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-N-benzyl-3-phenylprop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-N-[2-(4-chlorophenyl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
-
 Agaricus bisporus
1.14.18.1 (2E)-N-[2-(4-chlorophenyl)ethyl]-3-phenylprop-2-enamide
-
 Agaricus bisporus
1.14.18.1 3-hydroxycinnamic acid
-
 Agaricus bisporus
1.14.18.1 caffeic acid i.e. 3,4-dihydroxycinnamic acid Agaricus bisporus
1.14.18.1 Cinnamic acid
-
 Agaricus bisporus
1.14.18.1 hydroquinone
-
 Agaricus bisporus
1.14.18.1 kojic acid
-
 Agaricus bisporus
1.14.18.1 p-coumaric acid
-
 Agaricus bisporus
1.14.18.1 phenylethylamide
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.028
-
-
 Agaricus bisporus (2E)-N-benzyl-3-(4-hydroxyphenyl)prop-2-enamide
1.14.18.1 0.03
-
-
 Agaricus bisporus (2E)-3-(4-hydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide
1.14.18.1 0.037
-
-
 Agaricus bisporus hydroquinone
1.14.18.1 0.075
-
-
 Agaricus bisporus kojic acid
1.14.18.1 0.1
-
 IC50 above 0.1 mM Agaricus bisporus (2E)-3-phenyl-N-(2-phenylethyl)prop-2-enamide
1.14.18.1 0.1
-
 IC50 above 0.1 mM Agaricus bisporus (2E)-N-[2-(4-chlorophenyl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
1.14.18.1 0.1
-
 IC50 above 0.1 mM Agaricus bisporus (2E)-N-benzyl-3-phenylprop-2-enamide
1.14.18.1 0.1
-
 IC50 above 0.1 mM Agaricus bisporus (2E)-N-(4-chlorobenzyl)-3-phenylprop-2-enamide
1.14.18.1 0.1
-
 IC50 above 0.1 mM Agaricus bisporus (2E)-3-phenyl-N-(1-phenylethyl)prop-2-enamide
1.14.18.1 0.2
-
-
 Agaricus bisporus p-coumaric acid
1.14.18.1 0.25
-
-
 Agaricus bisporus (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
1.14.18.1 0.25
-
-
 Agaricus bisporus (2E)-N-benzyl-3-(3,4-dihydroxyphenyl)prop-2-enamide
1.14.18.1 0.35
-
-
 Agaricus bisporus (2E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxybenzyl)prop-2-enamide
1.14.18.1 0.35
-
-
 Agaricus bisporus (2E)-N-(3,4-dihydroxybenzyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
1.14.18.1 0.4
-
-
 Agaricus bisporus caffeic acid
1.14.18.1 0.6
-
-
 Agaricus bisporus (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]prop-2-enamide
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus Cinnamic acid
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus 3-hydroxycinnamic acid
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dihydroxyphenyl)ethyl]prop-2-enamide
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus (2E)-3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus (2E)-3-(4-methoxyphenyl)-N-(2-phenylethyl)prop-2-enamide
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus (2E)-N-[2-(4-chlorophenyl)ethyl]-3-phenylprop-2-enamide
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus (2E)-3-(4-chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]prop-2-enamide
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus (2E)-N-benzyl-3-(4-methoxyphenyl)prop-2-enamide
1.14.18.1 1
-
 IC50 above 1 mM Agaricus bisporus (2E)-3-(4-methoxyphenyl)-N-(1-phenylethyl)prop-2-enamide