EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.3.15 | expressed in Escherichia coli BL21 cells as a fusion protein with glutathione S-transferase | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.3.15 | 0.12 | - |
WSRYH | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 0.187 | - |
YWRDH | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 0.27 | - |
MWRHV | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 0.325 | - |
KDRNW | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 0.345 | - |
WTRGE | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 0.372 | - |
TKQTARKSTGGK | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 0.45 | - |
LDRGE | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 0.575 | - |
TSTGGRQGSHH | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.15 | additional information | Homo sapiens | a methylated lysine residue flanking the targeted arginine influences PAD-4-mediated deimination | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.3.15 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.3.15 | glutathione-Sepharose 4B column chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.15 | filaggrin L-Arg + H2O | - |
Homo sapiens | filaggrin L-citrulline + NH3 | - |
? | |
3.5.3.15 | histone H3 L-arginine + H2O | - |
Homo sapiens | histone H3 L-citrulline + NH3 | - |
? | |
3.5.3.15 | KDRNW + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.3.15 | LDRGE + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.3.15 | additional information | a methylated lysine residue flanking the targeted arginine influences PAD-4-mediated deimination | Homo sapiens | ? | - |
? | |
3.5.3.15 | additional information | no activity toward PVRAK, DQRTA, DVRIA, and EPRLF | Homo sapiens | ? | - |
? | |
3.5.3.15 | MWRHV + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.3.15 | N-alpha-benzoyl-L-arginine ethyl ester + H2O | - |
Homo sapiens | N-alpha-benzoyl-L-citrulline ethyl ester + NH3 | - |
? | |
3.5.3.15 | TKQTARKSTGGK + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.3.15 | TSTGGRQGSHH + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.3.15 | WSRYH + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.3.15 | WTRGE + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.3.15 | YWRDH + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.3.15 | PAD-4 | - |
Homo sapiens |
3.5.3.15 | peptidylarginine deiminase-4 | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.3.15 | 0.7 | - |
TKQTARKSTGGK | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 1.3 | - |
TSTGGRQGSHH | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 1.8 | - |
WSRYH | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 2 | - |
MWRHV | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 2 | - |
KDRNW | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 2.3 | - |
YWRDH | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 2.9 | - |
LDRGE | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens | |
3.5.3.15 | 3.3 | - |
WTRGE | in 60 mM MOPS buffer, pH 7.5 and 10 mM CaCl2, at 37°C | Homo sapiens |