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Literature summary extracted from

  • Brennan, L.A.; Lee, W.; Giblin, F.J.; David, L.L.; Kantorow, M.
    Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation (2009), Biochim. Biophys. Acta, 1790, 1665-1672.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Homo sapiens Q9UJ68
-
-
1.8.4.11 Mus musculus Q9D6Y7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 HLEB-3 cell
-
Homo sapiens
-
1.8.4.11 lens
-
Mus musculus
-
1.8.4.11 lens epithelial cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin
-
Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
r
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin
-
Mus musculus L-methionine + thioredoxin disulfide + H2O
-
r
1.8.4.11 additional information MsrA repairs methionine oxidized alpha-crystallin and restores the chaperone activity of alpha-crystallin lost upon methionine oxidation, Met-68 of alphabeta-crystallin is oxidized to protein methionine sulfoxide in the actual lens Homo sapiens ?
-
?
1.8.4.11 additional information MsrA repairs methionine oxidized alpha-crystallin and restores the chaperone activity of alpha-crystallin lost upon methionine oxidation, Met-68 of alphabeta-crystallin is oxidized to protein methionine sulfoxide in the actual lens Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
Homo sapiens
1.8.4.11 methionine sulfoxide reductase A
-
Mus musculus
1.8.4.11 MsrA
-
Homo sapiens
1.8.4.11 MsrA
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
Homo sapiens
1.8.4.11 thioredoxin
-
Mus musculus