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Literature summary extracted from
- Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4 (2009), Biochim. Biophys. Acta, 1790, 1575-1585.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.9 | cytosol | isoform Txnrd1 | Mus musculus | 5829 | - |
| 1.8.1.9 | mitochondrion | isoform Txnrd2 | Mus musculus | 5739 | - |
| 1.11.1.12 | cytosol | - |
Mus musculus | 5829 | - |
| 1.11.1.12 | mitochondrion | - |
Mus musculus | 5739 | - |
| 1.11.1.12 | nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | selenium | selenoenzyme | Mus musculus |  |
| 1.11.1.12 | selenium | - |
Mus musculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 20000 | - |
- |
Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.12 | glutathione + a lipid hydroperoxide | Mus musculus | - |
glutathione disulfide + lipid + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | Mus musculus | - |
- |
- |
| 1.11.1.12 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.11.1.12 | embryo | - |
Mus musculus | - |
| 1.11.1.12 | MEF cell | - |
Mus musculus | - |
| 1.11.1.12 | spermatozoon | - |
Mus musculus | - |
| 1.11.1.12 | testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | thioredoxin disulfide + NADPH + H+ | - |
Mus musculus | thioredoxin + NADP+ | - |
? | |
| 1.11.1.12 | glutathione + a lipid hydroperoxide | - |
Mus musculus | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | additional information | preferred substrates are found to be hydroperoxide groups of phosphatidylcholine and on cumene and t-butyl hydroperoxides | Mus musculus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.11.1.12 | monomer | - |
Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | thioredoxin reductase | - |
Mus musculus |
| 1.8.1.9 | Txnrd1 | isoform | Mus musculus |
| 1.8.1.9 | Txnrd2 | isoform | Mus musculus |
| 1.11.1.12 | glutathione peroxidase 4 | - |
Mus musculus |
| 1.11.1.12 | GPx4 | - |
Mus musculus |
| 1.11.1.12 | PHGPX | - |
Mus musculus |
| 1.11.1.12 | phospholipid hydroperoxide glutathione peroxidase | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | FAD | - |
Mus musculus | |
| 1.8.1.9 | NADPH | - |
Mus musculus | |
| 1.11.1.12 | glutathione | - |
Mus musculus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | malfunction | ablation of cytosolic thioredoxin reductase (Txnrd1) or mitochondrial thioredoxin reductase (Txnrd2) yields embryonic lethal phenotypes | Mus musculus |
| 1.8.1.9 | physiological function | isoform Txnrd1 but not Txnrd2 is required for cerebellar development | Mus musculus |
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Release 2023.1 (January 2023)
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