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Literature summary extracted from

  • Lamb, H.K.; Van den Hombergh, J.P.T.W.; Newton, G.H.; Moore, J.D.; Roberts, C.F.; Hawkins, A.R.
    Differential flux through the quinate and shikimate pathways. Implications for the channeling hypothesis (1992), Biochem. J., 284, 181-187.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.118 overexpression in Aspergillus nidulans Aspergillus nidulans

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.118 Aspergillus nidulans
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Synonyms

EC Number Synonyms Comment Organism
4.2.1.118 QutC
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 Aspergillus nidulans

General Information

EC Number General Information Comment Organism
4.2.1.118 physiological function constitutve overexpression leads to impaired growth in minimal medium which can be alleviated by the addition of aromatic amino acids to the medium. Overexpression of the qutC gene in mutant strains lacking protocatechuic acid oxygenase leads to the build up of protocatechuic acid in the medium. The metabolites 3-dehydroquinate and dehydroshikimate leak from the pentafunctional AROM protein at a rate comparable with the extent of flux catalysed by the AROM protein. The AROM protein has a low level channelling function probably as a result of the close juxtaposition of five active sites and this channelling function is only physiologically significant under non-optimal conditions of nutrient supply and oxygenation, when the organism is in situ in its natural environment Aspergillus nidulans