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Literature summary extracted from

  • Yang, M.; Sun, J.; Zhang, T.; Liu, J.; Zhang, J.; Shi, M.A.; Darakhshan, F.; Guerre-Millo, M.; Clement, K.; Gelb, B.D.; Dolgnov, G.; Shi, G.P.
    Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice (2008), Arterioscler. Thromb. Vasc. Biol., 28, 2202-2208.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.38 additional information enzyme deficiency leads to blocked adipogenesis in 3T3-L1 preadipocytes, while CatK overexpression leads to enhanced adipogenesis, phenotypes, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.38 CatK-selective inhibitor II i.e. Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z Homo sapiens
3.4.22.38 CatK-selective inhibitor II commercial preparation Mus musculus
3.4.22.38 E-64d
-
 Mus musculus
3.4.22.38 E64d
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.38 28000
-
 x * 28000, mature CatK, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.38 additional information Mus musculus deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism, reducing serum glucose and insulin levels, in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview ?
-
 ?
3.4.22.38 additional information Homo sapiens deficiency and inhibition of cathepsin K reduce preadipocyte adipogenesis, body weight gain, and increase glucose metabolism in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.38 Homo sapiens
-
-
-
3.4.22.38 Mus musculus
-
 female C57BL/6/129S mice, wild-type and ob/ob mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.38 3T3-L1 cell
-
 Mus musculus
-
3.4.22.38 adipose tissue
-
 Mus musculus
-
3.4.22.38 commercial preparation recombinant Homo sapiens
-
3.4.22.38 macrophage peritoneal Mus musculus
-
3.4.22.38 additional information no expression in skeletal muscle Mus musculus
-
3.4.22.38 additional information negligible expression in skeletal muscle Homo sapiens
-
3.4.22.38 preadipocyte
-
 Mus musculus
-
3.4.22.38 preadipocyte subcutaneous, the enzyme content is increased by 12fold during adipogenesis Homo sapiens
-
3.4.22.38 spleen
-
 Mus musculus
-
3.4.22.38 white adipose tissue
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.38 human plasma fibronectin + H2O recombinant enzyme Homo sapiens ?
-
 ?
3.4.22.38 additional information deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism, reducing serum glucose and insulin levels, in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview Mus musculus ?
-
 ?
3.4.22.38 additional information deficiency and inhibition of cathepsin K reduce preadipocyte adipogenesis, body weight gain, and increase glucose metabolism in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.38 ? x * 28000, mature CatK, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.22.38 catK
-
 Mus musculus
3.4.22.38 catK
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.38 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.38 5.5
-
 assay at Homo sapiens