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Literature summary extracted from

  • Koledin, T.; Newton, G.L.; Fahey, R.C.
    Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes (2002), Arch. Microbiol., 178, 331-337.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.189 expression in Escherichia coli Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.189 desacetylmycothiol + acetyl-CoA Mycobacterium tuberculosis this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme-A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA Mycobacterium tuberculosis H37Rv this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes mycothiol + coenzyme-A
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.189 Mycobacterium tuberculosis P9WJM7
-
-
2.3.1.189 Mycobacterium tuberculosis H37Rv P9WJM7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Mycobacterium tuberculosis mycothiol + coenzyme-A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes Mycobacterium tuberculosis mycothiol + coenzyme-A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA
-
 Mycobacterium tuberculosis H37Rv mycothiol + coenzyme-A
-
 ?
2.3.1.189 desacetylmycothiol + acetyl-CoA this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes Mycobacterium tuberculosis H37Rv mycothiol + coenzyme-A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.189 MshD
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.189 malfunction production of a Mycobacterium smegmatis transposon mutant blocked in the production of mycothill as the result of lacking the transacetylase activity of mycothiol synthase Mycobacterium tuberculosis