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Literature summary extracted from

  • Tsai, A.L.; Kulmacz, R.J.
    Prostaglandin H synthase: Resolved and unresolved mechanistic issues (2010), Arch. Biochem. Biophys., 493, 103-124.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.99.1 0.0009
-
 arachidonate purified isoform PGHS-2, method: coupled, homo-vanilic acid Homo sapiens
1.14.99.1 0.0011
-
 arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
1.14.99.1 0.0017
-
 arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
1.14.99.1 0.0019
-
 arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries
1.14.99.1 0.002
-
 arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
1.14.99.1 0.0027
-
 arachidonate purified isoform PGHS-1, method: coupled, homo-vanilic acid Ovis aries
1.14.99.1 0.003
-
 arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries
1.14.99.1 0.0037
-
 arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries
1.14.99.1 0.0045
-
 arachidonate purified isoform PGHS-1, method: direct, O2 Homo sapiens
1.14.99.1 0.005
-
 O2 purified isoform PGHS-1, method: direct, O2 Ovis aries
1.14.99.1 0.005
-
 arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
1.14.99.1 0.0051
-
 arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
1.14.99.1 0.0055
-
 O2 purified isoform PGHS-1, method: direct, O2 Ovis aries
1.14.99.1 0.009
-
 arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
1.14.99.1 0.0092
-
 arachidonate purified isoform PGHS-2, method: direct, O2 Homo sapiens
1.14.99.1 0.01
-
 O2 purified isoform PGHS-1, method: direct, arachidonate Ovis aries
1.14.99.1 0.01
-
 arachidonate purified isoform PGHS-2, method: direct, arachidonate Homo sapiens
1.14.99.1 0.01
-
 arachidonate purified isoform PGHS-2, method: direct, trimethyl phosphine oxide Homo sapiens
1.14.99.1 0.0102
-
 arachidonate purified isoform PGHS-1, method: direct, arachidonate Homo sapiens
1.14.99.1 0.011
-
 arachidonate purified isoform PGHS-1, method: coupled, homo-vanilic acid Ovis aries
1.14.99.1 0.011
-
 O2 purified isoform PGHS-1, method: direct, O2 Ovis aries
1.14.99.1 0.015
-
 arachidonate purified isoform PGHS-1, method: direct, O2 Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Homo sapiens P23219
-
-
1.14.99.1 Homo sapiens P35354
-
-
1.14.99.1 Ovis aries P05979
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.99.1
-
 Homo sapiens
1.14.99.1
-
 Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2 the reaction comprises two steps: dioxygenation of arachidonate to yield prostaglandin G2 containing both a 9-11 endoperoxide and a 15-peroxide group, and a peroxidase reaction, which converts prostaglandin G2 to prostaglandin H2 where the 15-peroxide is reduced to an alcohol Homo sapiens prostaglandin H2 + A + H2O
-
 ?
1.14.99.1 arachidonate + AH2 + O2 the reaction comprises two steps: dioxygenation of arachidonate to yield prostaglandin G2 containing both a 9-11 endoperoxide and a 15-peroxide group, and a peroxidase reaction, which converts prostaglandin G2 to prostaglandin H2 where the 15-peroxide is reduced to an alcohol Ovis aries prostaglandin H2 + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.1 PGHS-1 isoform Ovis aries
1.14.99.1 PGHS-1 isoform Homo sapiens
1.14.99.1 PGHS-2 isoform Homo sapiens
1.14.99.1 prostaglandin H synthase
-
 Homo sapiens
1.14.99.1 prostaglandin H synthase
-
 Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.99.1 heme
-
 Homo sapiens
1.14.99.1 heme
-
 Ovis aries