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Literature summary extracted from

  • Manta, B.; Hugo, M.; Ortiz, C.; Ferrer-Sueta, G.; Trujillo, M.; Denicola, A.
    The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2 (2009), Arch. Biochem. Biophys., 484, 146-154.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.24 H2O2 excess of H2O2 inactivates the enzyme by overoxidation Homo sapiens
1.11.1.24 peroxynitrite excess of peroxynitrite inactivates the enzyme by overoxidation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.1.24 0.0007
-
 H2O2 Km below 0.0007 mM, at 25°C and pH 7.4 Homo sapiens
1.11.1.24 0.0024
-
 reduced thioredoxin human thioredoxin, at 25°C Homo sapiens
1.11.1.24 0.004
-
 reduced thioredoxin Escherichia coli thioredoxin, at 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.24 additional information Homo sapiens peroxiredoxin 2 is a key antioxidant enzyme for the erythrocyte and renders red blood cells as active oxidant scrubbers in the bloodstream ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.24 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.24 DEAE-Sepharose column chromatography, Superdex 75 gel filtration, and Superdex 200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.24 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.24 H2O2 + reduced thioredoxin
-
 Homo sapiens H2O + oxidized thioredoxin
-
 ?
1.11.1.24 additional information peroxiredoxin 2 is a key antioxidant enzyme for the erythrocyte and renders red blood cells as active oxidant scrubbers in the bloodstream Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.11.1.24 decamer the enzyme exists as a decamer in vivo, the reduced protein is also a decamer composed of the association of non-covalently linked dimers Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.11.1.24 peroxiredoxin 2 previously known as torin, calpromotin, NKEF-B, HRPRP, band 8 or TPx-B Homo sapiens
1.11.1.24 Prx2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.24 thioredoxin
-
 Homo sapiens