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Literature summary extracted from

  • Saraiva, V.B.; Wengert, M.; Gomes-Quintana, E.; Heise, N.; Caruso-Neves, C.
    Na(+)-ATPase and protein kinase C are targets to 1-O-hexadecylphosphocoline (miltefosine) in Trypanosoma cruzi (2009), Arch. Biochem. Biophys., 481, 65-71.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.3 Ca2+ 67% activity after addition of EGTA Trypanosoma cruzi
7.2.2.3 Na+
-
 Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 Furosemide completely inhibited by 2 mM Trypanosoma cruzi
7.2.2.3 miltefosine 1-O-hexadecylphosphocholine Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Trypanosoma cruzi
-
 Y-strain
-
7.2.2.3 Trypanosoma cruzi Y-
-
 Y-strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
 Trypanosoma cruzi ADP + phosphate + Na+/out
-
 ?
7.2.2.3 ATP + H2O + Na+/in
-
 Trypanosoma cruzi Y- ADP + phosphate + Na+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+-ATPase
-
 Trypanosoma cruzi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.3 7
-
-
 Trypanosoma cruzi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.2.3 0.044
-
-
 Trypanosoma cruzi miltefosine
7.2.2.3 0.22
-
 in homogenate of clone CL14 Trypanosoma cruzi Furosemide