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Literature summary extracted from

  • Keener, W.K.; Arp, D.J.
    Kinetic studies of ammonia monooxygenase inhibition in Nitrosomonas europaea by hydrocarbons and halogenated hydrocarbons in an optimized whole-cell assay (1993), Appl. Environ. Microbiol., 59, 2501-2510.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.39 Bromoethane noncompetitive Nitrosomonas europaea
1.14.99.39 chloroethane noncompetitive Nitrosomonas europaea
1.14.99.39 Chloromethane noncompetitive Nitrosomonas europaea
1.14.99.39 chloropropane noncompetitive Nitrosomonas europaea
1.14.99.39 ethane noncompetitive Nitrosomonas europaea
1.14.99.39 ethylene competitive Nitrosomonas europaea
1.14.99.39 Iodoethane noncompetitive Nitrosomonas europaea
1.14.99.39 iodomethane noncompetitive Nitrosomonas europaea
1.14.99.39 methane competitive Nitrosomonas europaea
1.14.99.39 additional information active-site model for ammonia monooxygenase consisting of an NH3-binding site and a second site that binds noncompetitive inhibitors, with oxidation occurring at either site Nitrosomonas europaea
1.14.99.39 n-butane noncompetitive Nitrosomonas europaea
1.14.99.39 n-chloropropane noncompetitive Nitrosomonas europaea
1.14.99.39 propane noncompetitive Nitrosomonas europaea

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.39 Nitrosomonas europaea
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.99.39 NH3 + a reduced acceptor + O2 = NH2OH + an acceptor + H2O mechanism, active-site model for ammonia monooxygenase consisting of an NH3-binding site and a second site that binds noncompetitive inhibitors, with oxidation occurring at either site Nitrosomonas europaea

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.39 ammonia + AH2 + O2
-
Nitrosomonas europaea NH2OH + A + H2O
-
?
1.14.99.39 additional information active-site model for ammonia monooxygenase consisting of an NH3-binding site and a second site that binds noncompetitive inhibitors, with oxidation occurring at either site Nitrosomonas europaea ?
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.99.39 0.03
-
iodomethane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 0.03
-
Iodoethane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 0.13
-
iodomethane value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.22
-
Bromoethane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 0.22
-
ethane value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.29
-
Iodoethane value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.3
-
n-butane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 0.3
-
Chloromethane value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.44
-
propane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 0.49
-
Bromoethane value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.5
-
chloropropane value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.5
-
n-chloropropane value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.66
-
ethylene value derived from slope replot Nitrosomonas europaea
1.14.99.39 0.89
-
ethane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 0.92
-
n-butane value derived from slope replot Nitrosomonas europaea
1.14.99.39 1.01
-
chloroethane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 1.41
-
chloroethane value derived from slope replot Nitrosomonas europaea
1.14.99.39 1.42
-
chloroethane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 1.43
-
propane value derived from slope replot Nitrosomonas europaea
1.14.99.39 1.47
-
Chloromethane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 1.49
-
chloropropane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 1.49
-
n-chloropropane value derived from intercept replot Nitrosomonas europaea
1.14.99.39 3.24
-
methane value derived from slope replot Nitrosomonas europaea
1.14.99.39 5.15
-
chloroethane value derived from slope replot Nitrosomonas europaea