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Literature summary extracted from

  • Nasizadeh, S.; Thiman, L.; Persson, L.
    Sequence elements essential for the rapid turnover of Crithidia fasciculata ornithine decarboxylase (2008), Amino Acids, 34, 421-428.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.17 expression of wild-type and chimeric mutant enzymes in COS cells Crithidia fasciculata
4.1.1.17 expression of wild-type and chimeric mutant enzymes in COS cells Leishmania donovani

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.17 additional information construction of chimeric mutant enzymes consisting of sequence from the Crithidia fasciculata and the Leishmania donovani enzymes, e.g. exchanging the C-terminal PEST region, which show altered protein stability compared to the wild-type enzymes, overview Crithidia fasciculata
4.1.1.17 additional information construction of chimeric mutant enzymes consisting of sequence from the Crithidia fasciculata and the Leishmania donovani enzymes, e.g. exchanging the C-terminal PEST region, which show altered protein stability compared to the wild-type enzymes, overview Leishmania donovani

General Stability

EC Number General Stability Organism
4.1.1.17 Crithidia fasciculata ODC, in contrast to other phylogentically related enzymes, is rapidly degraded also in mammalian systems, and it contains several sequence elements essential for the rapid turnover of the protein, these regions are mainly located in the central part of the enzyme, overview, half-life of the wild-type enzyme is 3.2 h Crithidia fasciculata
4.1.1.17 Leishmania donovani ODC has a very fast turnover in mammalian cells, but is a stable enzyme, half-life of the wild-type enzyme is 5.5 h Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 additional information Crithidia fasciculata Crithidia fasciculata ODC, in contrast to other phylogentically related enzymes, is rapidly degraded also in mammalian systems, and it contains several sequence elements essential for the rapid turnover of the protein, these regions are mainly located in the central part of the enzyme, overview ?
-
 ?
4.1.1.17 additional information Leishmania donovani Leishmania donovani ODC has a very fast turnover in mammalian cells, but is a stable enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Crithidia fasciculata P90517
-
-
4.1.1.17 Leishmania donovani P27116
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 additional information Crithidia fasciculata ODC, in contrast to other phylogentically related enzymes, is rapidly degraded also in mammalian systems, and it contains several sequence elements essential for the rapid turnover of the protein, these regions are mainly located in the central part of the enzyme, overview Crithidia fasciculata ?
-
 ?
4.1.1.17 additional information Leishmania donovani ODC has a very fast turnover in mammalian cells, but is a stable enzyme Leishmania donovani ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 ODC
-
 Crithidia fasciculata
4.1.1.17 ODC
-
 Leishmania donovani

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.17 7.5
-
 assay at Crithidia fasciculata
4.1.1.17 7.5
-
 assay at Leishmania donovani