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Literature summary extracted from

  • Yang, S.; He, X.
    Re: Hadh2 and 3-hydroxyacyl-CoA dehydrogenase (2008), Am. J. Physiol. Endocrinol. Metab., 295, E987-E987.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.35 AMP-activated protein kinase
-
 Mus musculus

Application

EC Number Application Comment Organism
1.1.1.35 medicine lack of Hadh2 activity may impart early developmental problems, leading to embryo lethality. In addition to the 3-hydroxyacyl-CoA dehydrogenase activity, the HSD10 (formerly Hadh2) activity is also relevant to the metabolism and meiotic maturation of oocytes Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.35 oocyte in oocytes from diabetic mice, activity of Hadh2 is significantly reduced Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 acetoacetyl-CoA + NADH + H+ for the purpose of specifically measuring intracellular Hadh2 activities, branched-chain acyl-CoA thioesters, instead of acetoacetyl-CoA, shall be used as the substrate in either the forward or reverse reaction. In contrast to 3-hydroxyacyl-CoA dehydrogenase catalyzing the third reaction of straight-chain fatty acid oxidation spiral, HSD10 (formerly Hadh2) functions in isoleucine and steroid metabolism Mus musculus 3-hydroxybutyryl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
-
 Mus musculus
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase II
-
 Mus musculus
1.1.1.35 HADH
-
 Mus musculus
1.1.1.35 HADH2
-
 Mus musculus