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Literature summary extracted from

  • Rhee, S.H.; Kang, J.; Nahm, D.S.
    Cystatins and cathepsin B during orthodontic tooth movement (2009), Am. J. Orthod. Dentofacial. Orthop., 135, 99-105.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.1 diagnostics cathepsin B is a biologic marker reflecting the clinical state of inflammatory disease Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 cystatin
-
 Homo sapiens
3.4.22.1 iodoacetic acid
-
 Homo sapiens
3.4.22.1 additional information ruthenium(II)-arene compounds behave as powerful inhibitors Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.1 lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 Collagen + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.1 additional information Homo sapiens cathepsin B is an intracellular lysosomal cysteine proteinase that can degrade extracellular components including collagen and protein turnover in the lysosomal system. Cathepsin B plays an important role in the resolution of organic matrix, a final step in bone resorption. It is also known to play an important role in the initiation and perpetuation of inflammatory processes ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 gingival fluid from distal sulcus, in periodontitis Homo sapiens
-
3.4.22.1 tooth enzyme before and after canine extraction, force application reduces the enzyme activity in gingival crevicular fluid to 41.5% of maximal activity Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.1 additional information
-
 enzyme activity in gingival crevicular fluid of left and right sides, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 Collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.1 additional information cathepsin B is an intracellular lysosomal cysteine proteinase that can degrade extracellular components including collagen and protein turnover in the lysosomal system. Cathepsin B plays an important role in the resolution of organic matrix, a final step in bone resorption. It is also known to play an important role in the initiation and perpetuation of inflammatory processes Homo sapiens ?
-
 ?
3.4.22.1 Nalpha-benzoyl-Val-Lys-Lys-Arg-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.1 40
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.1 5.5
-
 assay at Homo sapiens