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Literature summary extracted from

  • Clayton, D.; Hanchapola, I.; Perlmutter, P.; Smith, A.I.; Aguilar, M.I.
    The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and beta-amino acid substrate analogs (2009), Adv. Exp. Med. Biol., 611, 559-560.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 angiotensin II C-terminal analogs screening of a library of angiotensin II C-terminal analogs identifies a number of tetrapeptides with increased ACE2 inhibition, and identifies residues critical to the binding of angiotensin II to the active site of ACE2 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.23 Zinc zinc carboxypeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Homo sapiens the enzyme is involved in the renin angiotensin system angiotensin-(1-7) + L-Phe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 heart the enzyme is upregulated in cardiovascular disease Homo sapiens
-
3.4.17.23 liver the enzyme is upregulated in fibrotic liver Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + L-Phe
-
 ?
3.4.17.23 angiotensin II + H2O the enzyme is involved in the renin angiotensin system Homo sapiens angiotensin-(1-7) + L-Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens
3.4.17.23 angiotensin II converting enzyme 2
-
 Homo sapiens