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Literature summary extracted from

  • Bianchet, M.A.; Erdemli, S.B.; Amzel, L.M.
    Structure, function, and mechanism of cytosolic quinone reductases (2008), Vitam. Horm., 78, 63-84.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 additional information is elevated in many tumors Mus musculus
1.6.5.2 additional information is elevated in many tumors Homo sapiens
1.6.5.2 additional information is elevated in many tumors Rattus norvegicus

Application

EC Number Application Comment Organism
1.6.5.2 medicine main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation Mus musculus
1.6.5.2 medicine main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation Homo sapiens
1.6.5.2 medicine main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagluation Rattus norvegicus
1.6.5.2 medicine plays a protective role against the induction of renal tumors by diethylstilbestrol Mesocricetus auratus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.6.5.2 apo QR1 and QR1 in complex with duroquinone, to 2.0 A resolution Homo sapiens
1.6.5.2 QR1 in complex with NADP+ or QR1 in complex with duroquinone Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
1.6.5.2 additional information QR1-deficient individuals exposed to occupational benzene are at a substantially higher risk of contracting leukemia than normal individuals Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 dicoumarol
-
 Homo sapiens
1.6.5.2 dicoumarol
-
 Mus musculus
1.6.5.2 dicoumarol
-
 Rattus norvegicus
1.6.5.2 ES936 is an irreversible mechanism-based inhibitor of QR1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.5.2 cytosol
-
 Mus musculus 5829
-
1.6.5.2 cytosol
-
 Homo sapiens 5829
-
1.6.5.2 cytosol
-
 Rattus norvegicus 5829
-
1.6.5.2 cytosol
-
 Mesocricetus auratus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Homo sapiens
-
-
-
1.6.5.2 Mesocricetus auratus
-
-
-
1.6.5.2 Mus musculus
-
-
-
1.6.5.2 Rattus norvegicus
-
-
-

Subunits

EC Number Subunits Comment Organism
1.6.5.2 dimer
-
 Mus musculus
1.6.5.2 dimer
-
 Homo sapiens
1.6.5.2 homodimer
-
 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 DT-diaphorase
-
 Mus musculus
1.6.5.2 DT-diaphorase
-
 Homo sapiens
1.6.5.2 DT-diaphorase
-
 Rattus norvegicus
1.6.5.2 DT-diaphorase
-
 Mesocricetus auratus
1.6.5.2 EC 1.6.99.2 formerly Mus musculus
1.6.5.2 EC 1.6.99.2 formerly Homo sapiens
1.6.5.2 EC 1.6.99.2 formerly Rattus norvegicus
1.6.5.2 EC 1.6.99.2 formerly Mesocricetus auratus
1.6.5.2 NAD(P)H:quinone acceptor oxidoreductase
-
 Mus musculus
1.6.5.2 NAD(P)H:quinone acceptor oxidoreductase
-
 Homo sapiens
1.6.5.2 NAD(P)H:quinone acceptor oxidoreductase
-
 Rattus norvegicus
1.6.5.2 NAD(P)H:quinone acceptor oxidoreductase
-
 Mesocricetus auratus
1.6.5.2 NQO1
-
 Mus musculus
1.6.5.2 NQO1
-
 Homo sapiens
1.6.5.2 NQO1
-
 Rattus norvegicus
1.6.5.2 NQO1
-
 Mesocricetus auratus
1.6.5.2 QR1
-
 Mus musculus
1.6.5.2 QR1
-
 Homo sapiens
1.6.5.2 QR1
-
 Rattus norvegicus
1.6.5.2 QR1
-
 Mesocricetus auratus
1.6.5.2 quinone reductase type 1
-
 Mus musculus
1.6.5.2 quinone reductase type 1
-
 Homo sapiens
1.6.5.2 quinone reductase type 1
-
 Rattus norvegicus
1.6.5.2 quinone reductase type 1
-
 Mesocricetus auratus
1.6.5.2 Vitamin K reductase
-
 Mus musculus
1.6.5.2 Vitamin K reductase
-
 Homo sapiens
1.6.5.2 Vitamin K reductase
-
 Rattus norvegicus
1.6.5.2 Vitamin K reductase
-
 Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 FAD
-
 Mus musculus
1.6.5.2 FAD
-
 Homo sapiens
1.6.5.2 FAD
-
 Rattus norvegicus
1.6.5.2 NADH
-
 Mus musculus
1.6.5.2 NADH
-
 Homo sapiens
1.6.5.2 NADH
-
 Rattus norvegicus
1.6.5.2 NADPH
-
 Mus musculus
1.6.5.2 NADPH
-
 Homo sapiens
1.6.5.2 NADPH
-
 Rattus norvegicus