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Literature summary extracted from

  • Orii, K.E.; Fukao, T.; Song, X.Q.; Mitchell, G.A.; Kondo, N.
    Liver-specific silencing of the human gene encoding succinyl-CoA: 3-ketoacid CoA transferase (2008), Tohoku J. Exp. Med., 215, 227-236.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.8.3.5 medicine hereditary SCOT deficiency is one cause of ketoacidosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.3.5 additional information the DNA region between -2168 and -361 appears to inhibit the SCOT promoter activity in HepG2 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.3.5 succinyl-CoA + a 3-oxo acid Homo sapiens
-
 succinate + a 3-oxoacyl-CoA
-
 ?
2.8.3.5 succinyl-CoA + acetoacetate Homo sapiens the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source succinate + acetoacetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.5 Homo sapiens P55809
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.5 Chang cell
-
 Homo sapiens
-
2.8.3.5 HeLa cell
-
 Homo sapiens
-
2.8.3.5 hepatoma cell line H1e human hepatoma cell line, but no detection in normal hepatocytes, HepG2 hepatoma cells and liver tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.5 succinyl-CoA + a 3-oxo acid
-
 Homo sapiens succinate + a 3-oxoacyl-CoA
-
 ?
2.8.3.5 succinyl-CoA + acetoacetate
-
 Homo sapiens succinate + acetoacetyl-CoA
-
 ?
2.8.3.5 succinyl-CoA + acetoacetate the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source Homo sapiens succinate + acetoacetyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.3.5 SCOT
-
 Homo sapiens
2.8.3.5 succinyl-CoA:3-ketoacid CoA transferase
-
 Homo sapiens