EC Number | Application | Comment | Organism |
---|---|---|---|
6.1.1.1 | biotechnology | a mutant Methanococcus jannaschii tyrosyl amber suppressor tRNA, Tyr MjtRNA CUR/tyrosyl-tRNA synthetase (MjTyrRS) pair is developed to uniquely incorporate phenylselenocysteine in response to the amber TAG codon in Escherichia coli. After being efficiently converted into dehydroalanine under mild conditions, Michael addition reactions with the corresponding thiols can be used to synthesize N-methyl- and N-acetyl-lysine analogues | Methanocaldococcus jannaschii |
6.1.1.4 | medicine | suppression of a tRNA gene mutation by increasing the steady-state levels of its cognate aminoacyl-tRNA synthetase is a model for potential therapies for human pathogenic tRNA mutations | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
6.1.1.4 | A3243G | respiratory chain defects in A3243G mutant cells is suppressed by overexpressing human mitochondrial leucyl-tRNA synthetase. The rates of oxygen consumption in suppressed cells are directly proportional to the levels of leucyl-tRNA synthetase. 15fold higher levels of leucyl-tRNA synthetase results in wild-type respiratory chain function. The suppressed cells have increased steady-state levels of tRNA(Leu(UUR)) and up to 3fold higher steady-state levels of mitochondrial translation products, but do not have rates of protein synthesis above those in parental mutant cells | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.1.1.1 | Methanocaldococcus jannaschii | - |
- |
- |
6.1.1.4 | Homo sapiens | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.1.1.1 | tyrosyltRNA synthetase | - |
Methanocaldococcus jannaschii |
6.1.1.4 | Leucyl-tRNA synthetase | - |
Homo sapiens |