EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.B40 | 0.000154 | - |
cortisol | enzyme from testis, cosubstrate NAD+, 37°C, pH not specified in the publication | Sus scrofa | |
1.1.1.B40 | 0.000208 | - |
cortisol | enzyme from bulbourethral gland, cosubstrate NAD+, 37°C, pH not specified in the publication | Sus scrofa | |
1.1.1.B40 | 0.000226 | - |
cortisol | enzyme from caput epididymidis, cosubstrate NAD+, 37°C, pH not specified in the publication | Sus scrofa | |
1.1.1.146 | 0.000237 | - |
cortisol | enzyme from caput epididymidis, cosubstrate NADP+, 37°C, pH not specified in the publication | Sus scrofa | |
1.1.1.146 | 0.000254 | - |
cortisol | enzyme from testis, cosubstrate NADP+, 37°C, pH not specified in the publication | Sus scrofa | |
1.1.1.146 | 0.000433 | - |
cortisol | enzyme from bulbourethral gland, cosubstrate NADP+, 37°C, pH not specified in the publication | Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.B40 | 44000 | - |
x * 44000, isoform 11betaHSD2, SDS-PAGE | Sus scrofa |
1.1.1.146 | 32000 | - |
x * 32000, isoform 11betaHSD1, SDS-PAGE | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | additional information | Sus scrofa | physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues | ? | - |
? | |
1.1.1.146 | additional information | Sus scrofa | physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.B40 | Sus scrofa | - |
- |
- |
1.1.1.146 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.B40 | bulbourethral gland | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
1.1.1.B40 | caput epididymis | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
1.1.1.B40 | cauda epididymis | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.B40 | corpus epididymis | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.B40 | prostate gland | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.B40 | testis | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
1.1.1.B40 | urethra | NAD+-dependent 11beta-hydroxysteroid dehydrogenase activity | Sus scrofa | - |
1.1.1.B40 | vas deferens | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.B40 | vesicular gland | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.146 | bulbourethral gland | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
1.1.1.146 | caput epididymis | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
1.1.1.146 | cauda epididymis | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.146 | corpus epididymis | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.146 | prostate gland | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.146 | testis | pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ | Sus scrofa | - |
1.1.1.146 | vas deferens | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
1.1.1.146 | vesicular gland | presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands | Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | cortisol + NAD+ | - |
Sus scrofa | cortisone + NADH | - |
r | |
1.1.1.B40 | additional information | physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues | Sus scrofa | ? | - |
? | |
1.1.1.B40 | additional information | maximal rates for NADP+-dependent cortisol oxidation are 7.4-28.5fold greater than the Vmax for NADPH-dependent reduction of cortisone, and are comparable with the rates of NAD+-dependent cortisol metabolism | Sus scrofa | ? | - |
? | |
1.1.1.146 | cortisol + NADP+ | - |
Sus scrofa | cortisone + NADPH | - |
r | |
1.1.1.146 | additional information | physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues | Sus scrofa | ? | - |
? | |
1.1.1.146 | additional information | maximal rates for NADP+-dependent cortisol oxidation are 7.4-28.5fold greater than the Vmax for NADPH-dependent reduction of cortisone, and are comparable with the rates of NAD+-dependent cortisol metabolism | Sus scrofa | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.B40 | ? | x * 44000, isoform 11betaHSD2, SDS-PAGE | Sus scrofa |
1.1.1.146 | ? | x * 32000, isoform 11betaHSD1, SDS-PAGE | Sus scrofa |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.B40 | 11betaHSD2 | - |
Sus scrofa |
1.1.1.B40 | NAD(+)-dependent 11beta-dehydrogenase | - |
Sus scrofa |
1.1.1.146 | 11betaHSD1 | - |
Sus scrofa |
1.1.1.146 | NADP(+)-dependent 11beta-dehydrogenase | - |
Sus scrofa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | NAD+ | - |
Sus scrofa | |
1.1.1.146 | NADP+ | - |
Sus scrofa |