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Literature summary extracted from

  • Sharp, V.; Thurston, L.M.; Fowkes, R.C.; Michael, A.E.
    11Beta-hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology (2007), Reproduction, 134, 473-482.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.B40 0.000154
-
cortisol enzyme from testis, cosubstrate NAD+, 37°C, pH not specified in the publication Sus scrofa
1.1.1.B40 0.000208
-
cortisol enzyme from bulbourethral gland, cosubstrate NAD+, 37°C, pH not specified in the publication Sus scrofa
1.1.1.B40 0.000226
-
cortisol enzyme from caput epididymidis, cosubstrate NAD+, 37°C, pH not specified in the publication Sus scrofa
1.1.1.146 0.000237
-
cortisol enzyme from caput epididymidis, cosubstrate NADP+, 37°C, pH not specified in the publication Sus scrofa
1.1.1.146 0.000254
-
cortisol enzyme from testis, cosubstrate NADP+, 37°C, pH not specified in the publication Sus scrofa
1.1.1.146 0.000433
-
cortisol enzyme from bulbourethral gland, cosubstrate NADP+, 37°C, pH not specified in the publication Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.B40 44000
-
x * 44000, isoform 11betaHSD2, SDS-PAGE Sus scrofa
1.1.1.146 32000
-
x * 32000, isoform 11betaHSD1, SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 additional information Sus scrofa physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues ?
-
?
1.1.1.146 additional information Sus scrofa physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Sus scrofa
-
-
-
1.1.1.146 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 bulbourethral gland pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ Sus scrofa
-
1.1.1.B40 caput epididymis pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ Sus scrofa
-
1.1.1.B40 cauda epididymis presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.B40 corpus epididymis presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.B40 prostate gland presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.B40 testis pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ Sus scrofa
-
1.1.1.B40 urethra NAD+-dependent 11beta-hydroxysteroid dehydrogenase activity Sus scrofa
-
1.1.1.B40 vas deferens presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.B40 vesicular gland presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.146 bulbourethral gland pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ Sus scrofa
-
1.1.1.146 caput epididymis pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ Sus scrofa
-
1.1.1.146 cauda epididymis presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.146 corpus epididymis presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.146 prostate gland presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.146 testis pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+ Sus scrofa
-
1.1.1.146 vas deferens presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-
1.1.1.146 vesicular gland presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+
-
Sus scrofa cortisone + NADH
-
r
1.1.1.B40 additional information physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues Sus scrofa ?
-
?
1.1.1.B40 additional information maximal rates for NADP+-dependent cortisol oxidation are 7.4-28.5fold greater than the Vmax for NADPH-dependent reduction of cortisone, and are comparable with the rates of NAD+-dependent cortisol metabolism Sus scrofa ?
-
?
1.1.1.146 cortisol + NADP+
-
Sus scrofa cortisone + NADPH
-
r
1.1.1.146 additional information physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues Sus scrofa ?
-
?
1.1.1.146 additional information maximal rates for NADP+-dependent cortisol oxidation are 7.4-28.5fold greater than the Vmax for NADPH-dependent reduction of cortisone, and are comparable with the rates of NAD+-dependent cortisol metabolism Sus scrofa ?
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.B40 ? x * 44000, isoform 11betaHSD2, SDS-PAGE Sus scrofa
1.1.1.146 ? x * 32000, isoform 11betaHSD1, SDS-PAGE Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11betaHSD2
-
Sus scrofa
1.1.1.B40 NAD(+)-dependent 11beta-dehydrogenase
-
Sus scrofa
1.1.1.146 11betaHSD1
-
Sus scrofa
1.1.1.146 NADP(+)-dependent 11beta-dehydrogenase
-
Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
Sus scrofa
1.1.1.146 NADP+
-
Sus scrofa