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Literature summary extracted from
- Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog (2009), Protein Expr. Purif., 63, 62-67.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.1.1.18 | optimization for expression in Escherichia coli | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.18 | glycine | - |
Homo sapiens |  |
| 5.1.1.18 | glycine | - |
Mus musculus | |
| 5.1.1.18 | L-erythro-3-hydroxyaspartate | - |
Homo sapiens | |
| 5.1.1.18 | L-erythro-3-hydroxyaspartate | - |
Mus musculus | |
| 5.1.1.18 | malonate | - |
Homo sapiens | |
| 5.1.1.18 | malonate | - |
Mus musculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.18 | 3.2 | - |
D-serine | pH 8.0 | Mus musculus | |
| 5.1.1.18 | 3.8 | - |
L-serine | pH 8.0 | Mus musculus | |
| 5.1.1.18 | 4.1 | - |
L-serine | pH 8.0 | Homo sapiens | |
| 5.1.1.18 | 10.8 | - |
D-serine | pH 8.0 | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.1.18 | Homo sapiens | - |
- |
- |
| 5.1.1.18 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.1.1.18 | recombinant enzyme | Homo sapiens |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.18 | 16.2 | - |
pH 8.0 | Mus musculus |
| 5.1.1.18 | 16.2 | - |
pH 8.0 | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.18 | L-serine | - |
Mus musculus | D-serine | - |
r | |
| 5.1.1.18 | L-serine | - |
Homo sapiens | D-serine | - |
r | |
| 5.1.1.18 | additional information | enzyme additionally catalyzes eleimination reaction of D-/L-serine and of L-serine-O-sulfate | Mus musculus | ? | - |
? | |
| 5.1.1.18 | additional information | enzyme additionally catalyzes elimination reaction of D-/L-serine and of L-serine-O-sulfate | Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.18 | 0.69 | - |
L-serine | pH 8.0 | Homo sapiens | |
| 5.1.1.18 | 0.78 | - |
L-serine | pH 8.0 | Mus musculus | |
| 5.1.1.18 | 1.41 | - |
D-serine | pH 8.0 | Homo sapiens | |
| 5.1.1.18 | 1.88 | - |
D-serine | pH 8.0 | Mus musculus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.18 | 0.011 | - |
L-erythro-3-hydroxyaspartate | - |
Homo sapiens | |
| 5.1.1.18 | 0.033 | - |
malonate | - |
Homo sapiens | |
| 5.1.1.18 | 0.043 | - |
L-erythro-3-hydroxyaspartate | - |
Mus musculus | |
| 5.1.1.18 | 0.071 | - |
malonate | - |
Mus musculus | |
| 5.1.1.18 | 0.366 | - |
glycine | - |
Homo sapiens | |
| 5.1.1.18 | 1.64 | - |
glycine | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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