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Literature summary extracted from

  • Lauber, T.; Tidten, N.; Matecko, I.; Zeeb, M.; Roesch, P.; Marx, U.C.
    Design and characterization of a soluble fragment of the extracellular ligand-binding domain of the peptide hormone receptor guanylyl cyclase-C (2009), Protein Eng. Des. Sel., 22, 1-7.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 expression of a Trx-tagged miniGC-C, comprising the extracellular domain, in Escherichia coli strain AD494(DE3) using expression vector pET-32a Sus scrofa

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 additional information recombinant miniGC-C, comprising the exracellular enzyme domain, binds the heat-stable enterotoxin STp-(5-17) with high affinity, ligand binding and structure analysis, overview Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 membrane GC-C Sus scrofa 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Sus scrofa guanylyl cyclase-C is a peptide hormone receptor 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Sus scrofa P55204
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.2 recombinant Trx-tagged miniGC-C, comprising the extracellular domain, from Escherichia coli strain AD494(DE3) by Co2+ affinity chromatography, dialysis and ultrafiltration, cleavage of the thioredoxin tag Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 intestine GC-C Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP guanylyl cyclase-C is a peptide hormone receptor Sus scrofa 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP guanylin-GC-C interaction, overview Sus scrofa 3',5'-cyclic GMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.6.1.2 More homology structure modeling of the extracellular domain of GC-C, GC-C structure analysis by NMR and fluorescence emission spectroscopy, overview Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 GC-C
-
 Sus scrofa
4.6.1.2 guanylyl cyclase-C
-
 Sus scrofa
4.6.1.2 peptide hormone receptor guanylyl cyclase-C
-
 Sus scrofa
4.6.1.2 STA
-
 Sus scrofa