Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vorland, M.; Holmsen, H.
    Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation (2008), Platelets, 19, 211-224.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 thrombin activation in a dose-dependent manner. Thrombin-induced PLD activity is dependent on autocrine stimulation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 membrane PLD1 and PLD2 are observed over the entire platelet mass. PLD1 is observed in small dots while PLD2 is concentrated close to the membrane. After stimulation with thrombin PLD1 and PLD2 rapidly translocate to the proximity of the plasma membrane of platelets Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.4 Ca2+ potentiates the activating effect of thrombin but Ca2+ alone does not activate PLD Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens O14939
-
-
3.1.4.4 Homo sapiens Q13393
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 blood platelet concentrated platelet-rich plasma is used Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + ethanol
-
 Homo sapiens choline + phosphatidylethanol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 phospholipase D1
-
 Homo sapiens
3.1.4.4 phospholipase D2
-
 Homo sapiens
3.1.4.4 PLD1
-
 Homo sapiens
3.1.4.4 PLD2
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.4 7.4
-
 assay at Homo sapiens