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Literature summary extracted from
- Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein (2008), Peptides, 29, 1472-1478.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | medicine | positive effect of prolyl oligopeptidase inhibitors on learning and memory in animal models for amnesia, enzyme activity measurements in patient samples and (neuro)peptide degradation studies link the enzyme with neurodegenerative disorders | Sus scrofa |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | expressed in Escherichia coli strain JM109 | Sus scrofa |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | S544A | mutant, lacking prolyl oligopeptidase activity | Sus scrofa |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | UAMC-00021 | - |
Sus scrofa |  |
| 3.4.21.26 | Z-Pro-prolinal | with high potency but relatively poor stability | Sus scrofa | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 80000 | - |
SDS-PAGE | Sus scrofa |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | additional information | Sus scrofa | stimulates the aggregation of alpha-synuclein | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | - |
Sus scrofa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | additional information | stimulates the aggregation of alpha-synuclein | Sus scrofa | ? | - |
? | |
| 3.4.21.26 | Z-Gly-Pro-p-nitroanilide + H2O | - |
Sus scrofa | Z-Gly-Pro + p-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | prolyl oligopeptidase | - |
Sus scrofa |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.0000016 | - |
- |
Sus scrofa | UAMC-00021 | |
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Release 2023.1 (January 2023)
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