EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | 5-fluorouracil | transfection with p53 induces resistance to 5-fluorouracil | Homo sapiens | |
2.1.1.45 | GW1843U89 | - |
Homo sapiens | |
2.1.1.45 | nolatrexed | transfection with p53 induces resistance to nolatrexed | Homo sapiens | |
2.1.1.45 | pemetrexed | transfection with p53 induces resistance to pemetrexed | Homo sapiens | |
2.1.1.45 | raltitrexed | transfection with p53 induces resistance to raltitrexed | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Homo sapiens | thymidylate synthase is a key enzyme in the de novo synthesis of dTMP | 7,8-dihydrofolate + dTMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.45 | colorectal cancer cell | - |
Homo sapiens | - |
2.1.1.45 | Lovo-175X2 cell | colorectal cancer cell, mutated subline of Lovo-92 cell | Homo sapiens | - |
2.1.1.45 | Lovo-273X17 cell | colorectal cancer cell, mutated subline of Lovo-92 cell | Homo sapiens | - |
2.1.1.45 | Lovo-92 cell | wildtype p53 colorectal cancer cell | Homo sapiens | - |
2.1.1.45 | Lovo-li cell | colorectal cancer cell harboring a functionally inactive p53 | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | 7,8-dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | thymidylate synthase is a key enzyme in the de novo synthesis of dTMP | Homo sapiens | 7,8-dihydrofolate + dTMP | - |
? |