BRENDA - Enzyme Database

Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase

Topalis, D.; Kumamoto, H.; Alexandre, J.A.; Dugue, L.; Pochet, S.; Berteina-Raboin, S.; Agrofoglio, L.A.; Deville-Bonne, D.; Nucleosides Nucleotides Nucleic Acids 26, 1369-1373 (2007)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.4.14
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.4.14
ATP + CMP
Homo sapiens
-
ADP + CDP
-
-
?
2.7.4.14
ATP + dCMP
Homo sapiens
-
ADP + dCDP
-
-
?
2.7.4.14
additional information
Homo sapiens
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.4.14
Homo sapiens
P30085
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.4.14
ATP + CMP
-
694478
Homo sapiens
ADP + CDP
-
-
-
?
2.7.4.14
ATP + dCMP
-
694478
Homo sapiens
ADP + dCDP
-
-
-
?
2.7.4.14
additional information
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
694478
Homo sapiens
?
-
-
-
-
2.7.4.14
additional information
substrate/product binding site determination and kinetics using MABA-CDP in a competition assay, overview
694478
Homo sapiens
?
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.4.14
ATP
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.4.14
ATP
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.4.14
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.4.14
ATP + CMP
Homo sapiens
-
ADP + CDP
-
-
?
2.7.4.14
ATP + dCMP
Homo sapiens
-
ADP + dCDP
-
-
?
2.7.4.14
additional information
Homo sapiens
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.4.14
ATP + CMP
-
694478
Homo sapiens
ADP + CDP
-
-
-
?
2.7.4.14
ATP + dCMP
-
694478
Homo sapiens
ADP + dCDP
-
-
-
?
2.7.4.14
additional information
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
694478
Homo sapiens
?
-
-
-
-
2.7.4.14
additional information
substrate/product binding site determination and kinetics using MABA-CDP in a competition assay, overview
694478
Homo sapiens
?
-
-
-
-