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Literature summary extracted from

  • An, S.; Barany, G.; Musier-Forsyth, K.
    Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase (2008), Nucleic Acids Res., 36, 2514-2521.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
6.1.1.15 A57G site-directed mutagenesis, the A57G mutation introduces a BstBI restriction site within the gene, but has no effect on catalytic activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.15 Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro Homo sapiens
-
AMP + diphosphate + L-prolyl-tRNAPro
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.15 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro
-
Homo sapiens AMP + diphosphate + L-prolyl-tRNAPro
-
?
6.1.1.15 ATP + L-proline + tRNAPro semi-synthetic human tRNAPro prepared by annealing a 5'-57-mer fragment to a 3'-16-mer. The 5'-57-mer is prepared by in vitro transcription Homo sapiens AMP + diphosphate + L-prolyl-tRNAPro
-
?
6.1.1.15 additional information substrate specificity, reducing effects of diverse different phosphorothioate substitutions in the 3'-strand of human tRNAPro on aminoacylation efficiency, mechanism, overview Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.15 class II prolyl-tRNA synthetase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.1.1.15 22
-
assay at room temperature Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.15 ATP
-
Homo sapiens